CAJ | 학술논문

目的探讨动脉瘤样纤维组织细胞瘤的临床特征及组织病理学诊断原则.方法回顾性分析5例动脉瘤样纤维组织细胞瘤患者的临床及病理资料.结果 5例患者中,男3例,女2例.皮损为暗红色或棕色结节,3例皮损近期突然增大；3例位于四肢,2例位于胸部和下颌.皮损组织病理学检查:均具有典型皮肤纤维瘤的组织学特征,同时见多数不规则出血性裂隙和囊腔结构,伴有含铁血黄素沉积；免疫组化示波形蛋白和CD68阳性,血管性标记(CD34和CD31)均阴性.结论鉴于AFH临床上具有近期快速增大的特点,组织学上显示出血性裂隙及囊腔形成,该肿瘤需要与血管肉瘤和血管瘤样纤维组织细胞瘤鉴别.
목적 탐토동맥류양섬유조직세포류적림상특정급조직병이학진단원칙.방법 회고성분석5례동맥류양섬유조직세포류환자적림상급병리자료.결과 5례환자중,남3례,녀2례.피손위암홍색혹종색결절,3례피손근기돌연증대；3례위우사지,2례위우흉부화하합.피손조직병이학검사:균구유전형피부섬유류적조직학특정,동시견다수불규칙출혈성렬극화낭강결구,반유함철혈황소침적；면역조화시파형단백화CD68양성,혈관성표기(CD34화CD31)균음성.결론 감우AFH림상상구유근기쾌속증대적특점,조직학상현시출혈성렬극급낭강형성,해종류수요여혈관육류화혈관류양섬유조직세포류감별.
Objective To understand the clinical and histopathologic diagnostic criteria for aneurysmal fibrous histiocytoma (AFH).Methods The clinical and histopathological features of 5 patients with AFH were retrospectively reviewed.Results There were 3 males and 2 females in these patients.All the tumors clinically manifested as dark erythematous or brown nodules.Three cases had a recent history of rapid growth.The lesions were located on the limbs (n =3),or chest and lower mandible (n =2).Histopathological examination of skin biopsies showed typical features of dermatofibroma,accompanied by many irregular cleftlike or cavernous blood-filled spaces with numerous hemosiderin pigments in all of these cases.Immunohistochemically,the tumor cells were immunoreactive to vimentin and CD68 but negative for CD34 or CD31.Conclusions In view of a history of recent rapid growth,the presence of hemorrhagic pseudocysts and high vascularity,AFH should be differentiated from angiosarcoma and angiomatoid fibrous histiocytoma.