CAJ | 학술논문

目的探讨术益纱作为肝组织创面止血修复材料的可行性. 方法在鼠肝脏左叶制造敞开型创面(5 mm×3 mm ×2 mm),形成出血模型.实验组使用术益纱贴敷创面,对照组贴敷速即纱.记录各组止血时间和总出血量,定期对创面进行肉眼观察和行组织学检查,研究术益纱的溶血率、急性毒性和细胞毒性. 结果术益纱溶血率为2.30%,最大耐受量>0.48 g/kg,细胞毒性为0级;术益纱止血时间为(5.00±0.00)s,总出血量为(0.88±0.18)g/kg,优于速即纱(P<0.05);术益纱在14 d降解完全,创面在21 d完全愈合,效果明显优于速即纱. 结论术益纱的溶血率、急性毒性和细胞毒性指标符合生物医用材料的要求,止血愈创效果显著,作用可能与其分子结构和黏附力有关.
목적 탐토술익사작위간조직창면지혈수복재료적가행성. 방법 재서간장좌협제조창개형창면(5 mm×3 mm ×2 mm),형성출혈모형.실험조사용술익사첩부창면,대조조첩부속즉사.기록각조지혈시간화총출혈량,정기대창면진행육안관찰화행조직학검사,연구술익사적용혈솔、급성독성화세포독성. 결과 술익사용혈솔위2.30%,최대내수량>0.48 g/kg,세포독성위0급;술익사지혈시간위(5.00±0.00)s,총출혈량위(0.88±0.18)g/kg,우우속즉사(P<0.05);술익사재14 d강해완전,창면재21 d완전유합,효과명현우우속즉사. 결론 술익사적용혈솔、급성독성화세포독성지표부합생물의용재료적요구,지혈유창효과현저,작용가능여기분자결구화점부력유관.
Objective To discuss the feasibility of Shuyisha as hemostasis and repair material for liver wound. Methods Hemolysis rate, acute toxicity and eytotoxicity of Shuyisha were measured. A hemorrhage model was established by making an open wound (5 mm× 3 nun ×2 mm) on the left liver lobe of mice. Hemostasis was performed with Shuyisha in experimental group and with Surgicel in control group, when the hemostatic time and total blood loss (TBL) were accurately recorded and regular macro-scopic and histological observation carried out. Results The hemolysis rate of Shuyisha was 2.33%, with maximum tolerance does of over 0.48 g/kg and the eytotoxicity at zero. The hemostatie time of Shuy-isha was (5.00 ±0.00) s, with total blood loss of (0.88±0.18) g/kg, better than Surgicel (P< 0.05). Shuyisha was degraded completely within 14 days, with the wound healed within 21 days in ex-perimental group, much better than Surgieel. Conclusions The hemolysis rate, acute toxicity and cy-totoxicity of Shuyisha are up to the requirement of biomedical materials. Shuyisha has effective hemosta-sis, which may be related to its molecular structure and adhesion.