CAJ | 학술논문

目的应用冠状动脉内多普勒超声评价白藜三醇对急性闭塞冠状动脉侧支循环的影响.方法将18头健康家猪随机分为3组:白藜三醇组、硝酸甘油组和对照组.通过闭胸法建立急性冠状动脉左回旋支(LCX)闭塞的动物模型,应用冠状动脉内多普勒超声测量LCX正常状态、急性闭塞后及药物干预后相关的血流频谱.结果在冠状动脉闭塞即刻,闭塞血管远端血流平均峰值流速(APV)明显低于正常水平[(0.85±0.25) cm/s比(24.83±3.43) cm/s,P＜0.05],持续观察60min,较闭塞即刻增加不明显[(0.83±0.24) cm/s比(0.85±0.25) cm/s,P＞0.05]；白藜三醇组及硝酸甘油组给药后,闭塞血管远端血流呈反向或双向,APV的绝对值[分别为(9.22±0.80) cm/s和(8.93±1.28)cm/s]明显高于闭塞即刻[分别为(0.84±0.21 )cm/s和(0.86±0.26) cm/s]及对照组[(0.86±0.22)cm/s](P均＜0.05),达峰值后数据绝对值逐渐减小,重复给药后数值再次增加；但2个给药组间比较差异无统计学意义；而白藜三醇组APV增高持续时间明显长于硝酸甘油组[2次给药总时间分别为(58.83±6.15) min比(21.80±5.79) min,P＜0.05].结论猪急性闭塞冠状动脉自身侧支循环建立明显不足.白藜三醇能够显著促进猪急性闭塞冠状动脉侧支循环的开放,且维持时间长于硝酸甘油.
목적 응용관상동맥내다보륵초성평개백려삼순대급성폐새관상동맥측지순배적영향.방법 장18두건강가저수궤분위3조:백려삼순조、초산감유조화대조조.통과폐흉법건립급성관상동맥좌회선지(LCX)폐새적동물모형,응용관상동맥내다보륵초성측량LCX정상상태、급성폐새후급약물간예후상관적혈류빈보.결과 재관상동맥폐새즉각,폐새혈관원단혈류평균봉치류속(APV)명현저우정상수평[(0.85±0.25) cm/s비(24.83±3.43) cm/s,P＜0.05],지속관찰60min,교폐새즉각증가불명현[(0.83±0.24) cm/s비(0.85±0.25) cm/s,P＞0.05]；백려삼순조급초산감유조급약후,폐새혈관원단혈류정반향혹쌍향,APV적절대치[분별위(9.22±0.80) cm/s화(8.93±1.28)cm/s]명현고우폐새즉각[분별위(0.84±0.21 )cm/s화(0.86±0.26) cm/s]급대조조[(0.86±0.22)cm/s](P균＜0.05),체봉치후수거절대치축점감소,중복급약후수치재차증가；단2개급약조간비교차이무통계학의의；이백려삼순조APV증고지속시간명현장우초산감유조[2차급약총시간분별위(58.83±6.15) min비(21.80±5.79) min,P＜0.05].결론 저급성폐새관상동맥자신측지순배건립명현불족.백려삼순능구현저촉진저급성폐새관상동맥측지순배적개방,차유지시간장우초산감유.
Objective To evaluate the impact of resveratrol on coronary collateral circulation in pigs suffered from experimental acute coronary occlusion.Methods Eighteen healthy pigs were randomly divided into 3 groups:resveratrol group,nitroglycerin group and control group.Animal model of acute coronary occlusion was established through PTCA method,and the blood flow spectrum in the left circumflex artery (LGX) was detected using intracoronary Doppler ultrasound.Results The average peak velocity (APV) in infarction correlation artery (IRA) was significantly decreased immediately after coronary occlusion [ (0.85 ± 0.25 ) cm/s vs.( 24.83 ± 3.43 ) cm/s,P ＜ 0.05 ].The APV remained unchanged during 0,30 and 60 minutes after the occlusion.Reversed or bidirectional blood flow was observed and the APV increased significantly [ (9.22 ± 0.80) cm/s vs.(0.84 ± 0.21 ) cm/s,(8.93 ± 1.28) cm/s vs.(0.86 ± 0.26 ) cm/s respectively,P ＜0.05] after the coronary injection of resveratrol (2 mg) or nitroglycerin (0.3 mg).There was no significant difference in peak APV between the resveratrol and nitroglycerin groups.The duration of increased APV was significantly longer in resveratrol group than that in nitroglycerin group [ (58.83 ±6.15)min vs.(21.80 ±5.79)min,P ＜0.05].Conclusions The collateral circulation after acute coronary occlusion was obviously insufficient in pigs.Resveratrol could significantly improve the blood flow in coronary collateral circulation after acute occlusion in this model.