CAJ | 학술논문

目的:以胶原蛋白为主要原料,配以中药苦参、板蓝根,通过适当的方法,制备一种用于宫颈创面止血、消炎并能加速创面愈合的新型栓剂材料.方法:制备高纯度的胶原蛋白溶液,栓剂基质,加入中药苦参、板蓝根制成栓剂,然后进行理化性能检测及质量监测、毒理学试验和药效学试验,并对其止血、消炎性能进行评价.结果:该栓剂质量稳定,pH值为5.5,毒理学试验均为阴性.药效学动物试验显示一期愈合率为90%,平均愈合时间为5～6 d.实验组与对照组相比较,止血和愈合的效果比较具差异有统计学意义(P<0.01).结论:参蓝胶原栓,既可止血、抗菌消炎,又有利于创面愈合、缩短愈合时间,具有临床应用价值.
목적:이효원단백위주요원료,배이중약고삼、판람근,통과괄당적방법,제비일충용우궁경창면지혈、소염병능가속창면유합적신형전제재료.방법:제비고순도적효원단백용액,전제기질,가입중약고삼、판람근제성전제,연후진행이화성능검측급질량감측、독이학시험화약효학시험,병대기지혈、소염성능진행평개.결과:해전제질량은정,pH치위5.5,독이학시험균위음성.약효학동물시험현시일기유합솔위90%,평균유합시간위5～6 d.실험조여대조조상비교,지혈화유합적효과비교구차이유통계학의의(P<0.01).결론:삼람효원전,기가지혈、항균소염,우유리우창면유합、축단유합시간,구유림상응용개치.
Objective:To take collagen as main ingredients plus herbal medicine Kushen(Radix Sophorae Flavescentis) and Banlangen (Radix Isatidis), a new suppository was prepared for anti-inflammation and elevating healing of uterine neck's wound. Methods: Add Kushen and Banlangen to the high purity collagen and base material to prepare the suppository. To evaluate the suppository's hemostatic effects and diminish inflammation by determination of physicochemical property and quality, toxicology and pharmacodynamics. Results: The quality of suppository was stable, pH was 5.5, the result of toxi-cology test was feminine. Pharmacodynamics test showed that the healing rate in preparation one was 90%. The average of healing time was five or six days. Compared with control group, the effects was more obvious (P<0.01).Conclusion: Shen-Lan-collagen suppository has excellent clinic curative value which possesses hemostatic effect and anti-inflammation effect hence it would be advance in the treatment of uterine neck's wound healing.