CAJ | 학술논문

目的探讨2型糖尿病(T2DM)患者遗传素质对膳食干预效果的影响,为T2DM患者制定个体化的膳食干预措施提供科学依据.方法随机抽取T2DM新发病例378例,检测其脂蛋白脂酶(LPL)基因S447多态性,根据基因型分为两组,一组为LPL S/X+X/X基因型(A组),另一组为S/S基因型(B组).然后仅对其进行饮食干预,2年随访结束后,共随访到依从性强的T2DM患者342例(A组60例,B组282例).检测两组患者的空腹血糖、血脂等指标.比较两组T2DM患者的血糖、血脂水平.结果在膳食干预前两组患者的空腹血糖、血脂等指标间差别无统计学意义(P＞0.05);但膳食干预后A组患者的血糖、三酰甘油水平低于B组,而高密度脂蛋白胆固酶高于B组,差别有统计学意义(P＜0.01).结论 T2DM人群膳食干预效果受自身遗传素质的影响;膳食干预对LPL S/X及X/X基因型患者的效果较S/S基因型患者明显.
목적 탐토2형당뇨병(T2DM)환자유전소질대선식간예효과적영향,위T2DM환자제정개체화적선식간예조시제공과학의거.방법 수궤추취T2DM신발병례378례,검측기지단백지매(LPL)기인S447다태성,근거기인형분위량조,일조위LPL S/X+X/X기인형(A조),령일조위S/S기인형(B조).연후부대기진행음식간예,2년수방결속후,공수방도의종성강적T2DM환자342례(A조60례,B조282례).검측량조환자적공복혈당、혈지등지표.비교량조T2DM환자적혈당、혈지수평.결과 재선식간예전량조환자적공복혈당、혈지등지표간차별무통계학의의(P＞0.05);단선식간예후A조환자적혈당、삼선감유수평저우B조,이고밀도지단백담고매고우B조,차별유통계학의의(P＜0.01).결론 T2DM인군선식간예효과수자신유전소질적영향;선식간예대LPL S/X급X/X기인형환자적효과교S/S기인형환자명현.
Objective To explore the effect of genetic predisposition on dietary intervention for T2DM patients to provide a scientific basis for development of individualized dietary interventions.Methods Three hundred seventy-eight new T2DM patients,randomly selected to determine their lipoprotein lipase (LPL) gene S447 polymorphism,were divided based on genotype into groups A (LPL S/X+X/X genotype) and B (S/S genotype).Dietary intervention was performed.The follow-up lasted 2 years.A total of 342 T2DM patients with good compliance (60 in group A,282 in group B) were followed up.The indexes such as fasting blood glucose (FBG) and lipid were detected.Results There was not significant difference in FBG and lipid between 2 groups before intervention (P＞0.05),but the levels of FBG,lipid were lower in group A than in group B after dietary intervention,the difference was significant (P＜0.05).Conclusion The effect of dietary intervention is affected by genetic predisposition in T2DM patients.Dietary intervention effects better in LPL S/X and X/X genotype patients than in S/S.