CAJ | 학술논문

背景:课题组已成功利用左旋聚乳酸的有限固定强度和可吸收的特性制成了新型颈椎可吸收固定板.目的:进行动物体内降解和力学实验,以测定新型可吸收颈椎左旋聚乳酸固定板的生物力学性能.方法:将长30 mm,宽5.5 mm,厚度为2.0 mm的试样经环氧乙烷消毒后,植入至15只兔的背部肌肉内,分别于术后1,3,5,7个月取出,观察材料的降解变化和机械性能的变化.结果与结论:植入1～5个月,外观观察材料植入体内后未发生明显改变.植入1～7个月材料体积和质量均未发生明显改变.植入1个月冲击强度未发生明显变化,植入3个月略有下降,后又逐渐上升,至7个月时达到甚至超过术前水平.植入后随着时间延长左旋聚乳酸板的弯曲强度呈逐渐下降趋势,但7个月内下降幅度并不显著.术后3～7个月扭转强度略有下降,但并不明显.结果表明,左旋聚乳酸的生物力学强度足够维持骨性融合的全过程,用其制成的颈椎前路固定板可以用于颈椎前路手术的植骨融合固定.
배경:과제조이성공이용좌선취유산적유한고정강도화가흡수적특성제성료신형경추가흡수고정판.목적:진행동물체내강해화역학실험,이측정신형가흡수경추좌선취유산고정판적생물역학성능.방법:장장30 mm,관5.5 mm,후도위2.0 mm적시양경배양을완소독후,식입지15지토적배부기육내,분별우술후1,3,5,7개월취출,관찰재료적강해변화화궤계성능적변화.결과여결론:식입1～5개월,외관관찰재료식입체내후미발생명현개변.식입1～7개월재료체적화질량균미발생명현개변.식입1개월충격강도미발생명현변화,식입3개월략유하강,후우축점상승,지7개월시체도심지초과술전수평.식입후수착시간연장좌선취유산판적만곡강도정축점하강추세,단7개월내하강폭도병불현저.술후3～7개월뉴전강도략유하강,단병불명현.결과표명,좌선취유산적생물역학강도족구유지골성융합적전과정,용기제성적경추전로고정판가이용우경추전로수술적식골융합고정.
BACKGROUND: Previous study has prepared a novel absorbable fixation plates utilizing the limited fixation strength and absorbable characteristics of poly-L-lactic acid (PLLA).OBJECTIVE: To test the mechanical property of PLLA absorbable fixation plates by in vivo degradation and mechanics experiments.METHODS: Fixation plates with 30 mm length, 5.5 mm width, and 2.0 mm thickness were selected. After ethylene oxide sterilization, the plates were implanted to the back muscles of 15 rabbits. At 1, 3, 5 and 7 months after operation, the plates were removed and the biodegradability and mechanical variation were observed.RESULTS AND CONCLUSION: No significant change appeared in appearance after the materials were implanted in vivo at 1-5months. There was no obvious change in volume and quality after 1-7 months. Mechanical test results showed that impact strength changed insignificantly after 1 month, followed a slight decrease after 3 months, then increased gradually, which met or exceeded the level before surgery at the end of 7 months. Bending strength decreased gradually over time with insignificant amplitude at 7 months after surgery. Torsional strength decreased insignificantly at 3-7 months after surgery. The results demonstrated that bio-mechanical strength of PLLA is sufficient to maintain the whole process of bony fusion. Anterior cervical fixation plate made of PLLA can be used for anterior cervical fusion and fixation.