国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2008年
6期
458-461
,共4页
直肠肿瘤%药物疗法%放射疗法
直腸腫瘤%藥物療法%放射療法
직장종류%약물요법%방사요법
Rectal neoplasms%Drug therapy%Radiotherapy
局部晚期直肠癌的术前同步放化疗可明显提高局控率,对于达到病理完全缓解的患者还可提高生存率,但临床疗效个体差异大.近年来研究发现,存活素、P53和P21、端粒酶、生长激素受体(GHR)、自身抗原ku70、凋亡蛋白Bax、抗凋亡蛋白Bcl-2、肿瘤增殖标记物Ki67、血管内皮生长因子(VEGF)等与直肠癌术前同步放化疗的敏感性相关,可预测术前放化疗的敏感性.
跼部晚期直腸癌的術前同步放化療可明顯提高跼控率,對于達到病理完全緩解的患者還可提高生存率,但臨床療效箇體差異大.近年來研究髮現,存活素、P53和P21、耑粒酶、生長激素受體(GHR)、自身抗原ku70、凋亡蛋白Bax、抗凋亡蛋白Bcl-2、腫瘤增殖標記物Ki67、血管內皮生長因子(VEGF)等與直腸癌術前同步放化療的敏感性相關,可預測術前放化療的敏感性.
국부만기직장암적술전동보방화료가명현제고국공솔,대우체도병리완전완해적환자환가제고생존솔,단림상료효개체차이대.근년래연구발현,존활소、P53화P21、단립매、생장격소수체(GHR)、자신항원ku70、조망단백Bax、항조망단백Bcl-2、종류증식표기물Ki67、혈관내피생장인자(VEGF)등여직장암술전동보방화료적민감성상관,가예측술전방화료적민감성.
Preoperative radiochemotherapy for locally advanced rectal cancer can improve local control rate obviously and ameliorate survival rate for pathologically complete response. However the clinical response is different among patients. Recently, clinical study and basic research results suggest survivin, p53/p21, telom-erase, growth hormone receptor(GHR), ku70, Bax, Bcl-2, Ki67 and vascular endothelial growth factor (VEGF) are related to the sensitivity of preoperative concurrent radiochemotherapy. They can be used to pre-dict sensitivity of preoperative radiochemotherapy.
