CAJ | 학술논문

目的建立迅速减压肺损伤的动物模型,为研究迅速减压肺损伤提供平台. 方法健康一级新西兰白兔30只,分为4组,放入迅速减压舱内,舱内压力在0.3 S内由53.3 kPa迅速降低至19.3 kPa,停留3～5 S后,在1 min内迅速将减压舱压力恢复至正常地面大气压力. 结果随着与气管相联的排气装置排气口直径的减小,各组动物肺脏损伤逐渐加重,肺脏内减压峰值升高(F=129.987,P<0.01). 结论该迅速减压动物模型能够模拟肺脏内不同的减压峰值,客观地体现胸廓及膈肌在飞机增压座舱发生高空迅速减压时对肺脏的保护作用,为深入研究迅速减压肺损伤以及探讨机体对减压峰值的耐限问题提供了可靠手段.
목적 건립신속감압폐손상적동물모형,위연구신속감압폐손상제공평태. 방법 건강일급신서란백토30지,분위4조,방입신속감압창내,창내압력재0.3 S내유53.3 kPa신속강저지19.3 kPa,정류3～5 S후,재1 min내신속장감압창압력회복지정상지면대기압력. 결과 수착여기관상련적배기장치배기구직경적감소,각조동물폐장손상축점가중,폐장내감압봉치승고(F=129.987,P<0.01). 결론 해신속감압동물모형능구모의폐장내불동적감압봉치,객관지체현흉곽급격기재비궤증압좌창발생고공신속감압시대폐장적보호작용,위심입연구신속감압폐손상이급탐토궤체대감압봉치적내한문제제공료가고수단.
Objective To establish an animal model of lung injury caused by rapid decompression. Methods Thirty New Zealand white rabbits were randomly divided into 4 groups and were placed in rapid decompression chamber which pressure was decompressed from 53.3 kPa to 19.3 kPa within 0.3 s and then returned to ground atmospheric level within 1 min after 3-5 s staying.Results By changing the diameter of releaser, which conducted with trachea, from 5 to 2 mm the lung injury of rabbits was aggravated and the rapid decompression peak values of every group increased (F=129.987, P<0. 01). Conclusions The animal model can be used for getting the peak value of lung pressure in different rapid decompression environment and objectively reflecting the protective effect of thorax and midriff when pressured chamber is rapidly decompressed at high altitude. It also provides a reliable method to further studies on lung injury and physiological resistance limit.