中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2011年
4期
309-312
,共4页
卢山%宋修峰%林松%李志清%李威
盧山%宋脩峰%林鬆%李誌清%李威
로산%송수봉%림송%리지청%리위
青光眼%磁共振成像,弥散%视通路%部分各向异性%弥散张量成像
青光眼%磁共振成像,瀰散%視通路%部分各嚮異性%瀰散張量成像
청광안%자공진성상,미산%시통로%부분각향이성%미산장량성상
Glaucoma%Diffusion magnetic resonance imaging%Visual pathways%Fractional anisotropy%Diffusion tensor imaging
目的 采用磁共振弥散张量成像(DTI)检测慢性闭角型青光眼(PACG)患者脑白质病变，用各向异性指数(FA)改变分析病变部位。方法 回顾性分析2008-2009年在天津医科大学总医院眼科就诊并行颅脑MRI检查患者的临床资料，其中确诊为慢性PACG并同时行DTI扫描的患者25例为慢性PACG组，根据视野损害程度分为轻度组和重度组；选取同一时间段行颅脑DTI扫描的健康人25例为正常对照组。采用FSL和DTIstudio软件处理原始数据得到FA图，输入SPM5软件做标准化处理，然后进行灰白质分割，对分割后的白质FA图进行平滑处理，最后对慢性PACG组和正常对照组FA图进行两样本t检验比较，采用FWE方法校正统计结果，取P＜0.05有统计学意义，将结果叠加于标准模板，显示阈值设定为10个体素。采用同样方法分析慢性PACG轻度组和重度组FA图差异。结果剔除头动明显受试者图像后，慢性PACG组和正常对照组各有22例入组，慢性PACG组分为轻度组13例、重度组9例。与正常对照组比较，慢性PACG患者双侧视束脚周段FA值明显降低(P＜0.05,FWE校正)，左侧包含98个体素，右侧包含56个体素。慢性PACG轻度组与重度组FA值差异无统计学意义(P＞0.05)。结论 DTI可检测慢性PACG患者脑白质结构病变。FA值可反应双侧视束脚周段病变。
目的 採用磁共振瀰散張量成像(DTI)檢測慢性閉角型青光眼(PACG)患者腦白質病變，用各嚮異性指數(FA)改變分析病變部位。方法 迴顧性分析2008-2009年在天津醫科大學總醫院眼科就診併行顱腦MRI檢查患者的臨床資料，其中確診為慢性PACG併同時行DTI掃描的患者25例為慢性PACG組，根據視野損害程度分為輕度組和重度組；選取同一時間段行顱腦DTI掃描的健康人25例為正常對照組。採用FSL和DTIstudio軟件處理原始數據得到FA圖，輸入SPM5軟件做標準化處理，然後進行灰白質分割，對分割後的白質FA圖進行平滑處理，最後對慢性PACG組和正常對照組FA圖進行兩樣本t檢驗比較，採用FWE方法校正統計結果，取P＜0.05有統計學意義，將結果疊加于標準模闆，顯示閾值設定為10箇體素。採用同樣方法分析慢性PACG輕度組和重度組FA圖差異。結果剔除頭動明顯受試者圖像後，慢性PACG組和正常對照組各有22例入組，慢性PACG組分為輕度組13例、重度組9例。與正常對照組比較，慢性PACG患者雙側視束腳週段FA值明顯降低(P＜0.05,FWE校正)，左側包含98箇體素，右側包含56箇體素。慢性PACG輕度組與重度組FA值差異無統計學意義(P＞0.05)。結論 DTI可檢測慢性PACG患者腦白質結構病變。FA值可反應雙側視束腳週段病變。
목적 채용자공진미산장량성상(DTI)검측만성폐각형청광안(PACG)환자뇌백질병변，용각향이성지수(FA)개변분석병변부위。방법 회고성분석2008-2009년재천진의과대학총의원안과취진병행로뇌MRI검사환자적림상자료，기중학진위만성PACG병동시행DTI소묘적환자25례위만성PACG조，근거시야손해정도분위경도조화중도조；선취동일시간단행로뇌DTI소묘적건강인25례위정상대조조。채용FSL화DTIstudio연건처리원시수거득도FA도，수입SPM5연건주표준화처리，연후진행회백질분할，대분할후적백질FA도진행평활처리，최후대만성PACG조화정상대조조FA도진행량양본t검험비교，채용FWE방법교정통계결과，취P＜0.05유통계학의의，장결과첩가우표준모판，현시역치설정위10개체소。채용동양방법분석만성PACG경도조화중도조FA도차이。결과척제두동명현수시자도상후，만성PACG조화정상대조조각유22례입조，만성PACG조분위경도조13례、중도조9례。여정상대조조비교，만성PACG환자쌍측시속각주단FA치명현강저(P＜0.05,FWE교정)，좌측포함98개체소，우측포함56개체소。만성PACG경도조여중도조FA치차이무통계학의의(P＞0.05)。결론 DTI가검측만성PACG환자뇌백질결구병변。FA치가반응쌍측시속각주단병변。
Objective To evaluate the brain white matter abnormality in the chronic primary angleclosure glaucoma (PACG) subjects with magnetic resonance diffusion tensor imaging (DTI), and to identify the abnormal regions in white matter based on altered fractional anisotropy (FA). Methods A retrespective study was conducted on the data of patients who underwent brain magnetic resonance imaging (MRI) at Department of Ophthalmology, Tianjin Medical University General Hospital between 2008 and 2009. Twenty-five patients who were proved to have chronic PACG and received brain DTI scan were recruited in the study (chronic PACG group), and were further stratified into the mild chronic PACG group and the severe chronic PACG group according to severity of visual field loss. A contemporary cohort of 25 healthy subjects who also underwent brain DTI scan was recruited as normal controls. FSL and Dtlstudio software were applied to process the raw data and to calculate the FA map which was then entered into the SPM5 software for normalization and grey/white matter segmentation. Then the segmented FA map of white matter was smoothed.Two-sample t test was used to compare the FA map in the chronic PACG group and the normal control group.The comparison was further controlled by family-wise error (FEW). Significantly different regions (as defined by P value less than 0.05) were overlaid on the normalized template, with the display threshold being 10 voxels. The same algorithm was used to compare the FA map between mild and severe chronic PACG groups.Results Each three subjects from the chronic PACG group and the normal control group were excluded due to obvious head motion, so that there were 22 subjects in each group. The chronic PACG group comprised 13 cases of mild and 9 of severe chronic PACG. Compared with the normal controls, the FA value at the root of bilateral optic tracts was significantly reduced among patients with chronic PACG (98 voxels on the left and 56 voxels on the right, P＜0.05, adjusted by FEW). There was no difference in FA value between the mild and severe chronic PACG groups (P＞0.05). Conclusions DTI can be used to investigate the brain white matter changes in chronic PACG. FA value may be a useful indicator for abnormality at the root of bilateral optic tracts.
