CAJ | 학술논문

目的定量分析肺癌计划CT与千伏级锥形束CT (KVCBCT)应用形变配准软件自动勾画危及器官可行性.方法选取5例肺癌患者1套定位CT图像和各10套摆位验证KVCBCT图像进行形变配准自动勾画和手工勾画危及器官,比较形变配准和刚性配准后的Dice相似性系数( DSC)、敏感性等差异,并行配对t检验.结果形变配准和刚性配准在体表轮廓、左肺、右肺、心脏、脊髓的DSC值分别为0.971和0.980(t=3.89,P=0.000)、0.836和0.873(t=4.41,P=0.000)、0.873和0.888(t=3.88,P=0.000)、0.738和0.764(t=4.83,P=0.000)、0.666和0.677(t=2.04,P =0.047)；敏感性分别为0.975和0.981(t=1.41,P=0.003)、0.914和0.803(t=-6.88,P=0.000)、0.926和0.800(t=-7.06,P=0.045)、0.782和0.708(t=-2.50,P=0.040)、0.625和0.796(t=-9.09,P=0.000).结论利用形变配准进行器官轮廓自动勾画差异小于刚性配准,体表轮廓、左右肺形变配准轮廓自动勾画效果优于心脏和脊髓的轮廓自动勾画.
목적 정량분석폐암계화CT여천복급추형속CT (KVCBCT)응용형변배준연건자동구화위급기관가행성.방법 선취5례폐암환자1투정위CT도상화각10투파위험증KVCBCT도상진행형변배준자동구화화수공구화위급기관,비교형변배준화강성배준후적Dice상사성계수( DSC)、민감성등차이,병행배대t검험.결과 형변배준화강성배준재체표륜곽、좌폐、우폐、심장、척수적DSC치분별위0.971화0.980(t=3.89,P=0.000)、0.836화0.873(t=4.41,P=0.000)、0.873화0.888(t=3.88,P=0.000)、0.738화0.764(t=4.83,P=0.000)、0.666화0.677(t=2.04,P =0.047)；민감성분별위0.975화0.981(t=1.41,P=0.003)、0.914화0.803(t=-6.88,P=0.000)、0.926화0.800(t=-7.06,P=0.045)、0.782화0.708(t=-2.50,P=0.040)、0.625화0.796(t=-9.09,P=0.000).결론 이용형변배준진행기관륜곽자동구화차이소우강성배준,체표륜곽、좌우폐형변배준륜곽자동구화효과우우심장화척수적륜곽자동구화.
Objective To quantitative analysis the difference of organ contour using planning CT and kilovolt cone beam CT (KVCBCT) deformable registration.Methods One set planning CT image and ten sets of KVCBCT image of one patient were choose and total five patients.Organ contour were automatic outlined to using deformable registration.To compare the organ contours different of deformable registration (DR) and rigid registration (RR).Statistic analysis was executed with paired t-test for dice similarity coefficient (DSC) value and sensitiveness (SENS) value.Results The DSC value of body,left,right lung,heart and spinal respectively:0.971 and 0.980 ( t =3.89,P =0.000 ),0.836 and 0.873 ( t =4.41,P =0.000),0.873 and 0.888 ( t =3.88,P =0.000 ),0.738 and 0.764 ( t =4.83,P =0.000 ),0.666 and 0.677 ( t =2.04,P =0.047 ).The SENS value:0.975 and 0.981 ( t =1.41,P =0.003 ),0.914 and 0.803(t=-6.88,P=0.000),0.926 and 0.800(t=-7.06,P=0.045),0.782 and 0.708(t=-2.50,P=0.040),0.625 and 0.796 (t =-9.09,P =0.000).Conclusions RR is at a competitive disadvantage in terms of organ contour outline.The body,left and right lung that are used DR have advantage over the heart and spinal.