中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
21期
7-9
,共3页
陈清%苏卫东%瞿尔力%黄育丹%邓秀睿
陳清%囌衛東%瞿爾力%黃育丹%鄧秀睿
진청%소위동%구이력%황육단%산수예
婴儿,新生%诱发电位,听觉,脑干%血清白蛋白%总胆红素%胆红素神经毒性
嬰兒,新生%誘髮電位,聽覺,腦榦%血清白蛋白%總膽紅素%膽紅素神經毒性
영인,신생%유발전위,은각,뇌간%혈청백단백%총담홍소%담홍소신경독성
Infant,newborn%Evoked potentials,auditory,brain stem%Serum albumin%Total bilirubin%Bilirubin neurotoxicity
目的 探讨新生儿血清总胆红素/白蛋白在预测胆红素神经毒性方面的临床意义.方法 选择2007年5月至2010年8月住院治疗的高胆红素血症新生儿83例,检测其血清总胆红素和白蛋白等,并计算血清总胆红素/白蛋白,同时根据脑干听觉诱发电位(BAEP)的检测结果分为BAEP正常组和BAEP异常组,并对比观察.结果 BAEP异常组27例,BAEP正常组56例,BAEP 异常组的血清总胆红素、血清总胆红素/白蛋白均显著高于BAEP正常组[(356.50±59.23)μmol/L比(318.70±55.12)μmol/L、(5.02±0.49)×10-3比(4.56±0.43)×10-3],差异有统计学意义(P<0.05);多元回归分析显示:BAEP异常与血清总胆红素/白蛋白密切相关(r=0.72,P<0.05),而与血清总胆红素无明显相关性(r=0.19,P>0.05).结论 血清总胆红素/白蛋白较血清总胆红素更能反映高胆红素血症新生儿血中游离胆红素的水平,可作为评估胆红素神经毒性危险因素的指标之一.
目的 探討新生兒血清總膽紅素/白蛋白在預測膽紅素神經毒性方麵的臨床意義.方法 選擇2007年5月至2010年8月住院治療的高膽紅素血癥新生兒83例,檢測其血清總膽紅素和白蛋白等,併計算血清總膽紅素/白蛋白,同時根據腦榦聽覺誘髮電位(BAEP)的檢測結果分為BAEP正常組和BAEP異常組,併對比觀察.結果 BAEP異常組27例,BAEP正常組56例,BAEP 異常組的血清總膽紅素、血清總膽紅素/白蛋白均顯著高于BAEP正常組[(356.50±59.23)μmol/L比(318.70±55.12)μmol/L、(5.02±0.49)×10-3比(4.56±0.43)×10-3],差異有統計學意義(P<0.05);多元迴歸分析顯示:BAEP異常與血清總膽紅素/白蛋白密切相關(r=0.72,P<0.05),而與血清總膽紅素無明顯相關性(r=0.19,P>0.05).結論 血清總膽紅素/白蛋白較血清總膽紅素更能反映高膽紅素血癥新生兒血中遊離膽紅素的水平,可作為評估膽紅素神經毒性危險因素的指標之一.
목적 탐토신생인혈청총담홍소/백단백재예측담홍소신경독성방면적림상의의.방법 선택2007년5월지2010년8월주원치료적고담홍소혈증신생인83례,검측기혈청총담홍소화백단백등,병계산혈청총담홍소/백단백,동시근거뇌간은각유발전위(BAEP)적검측결과분위BAEP정상조화BAEP이상조,병대비관찰.결과 BAEP이상조27례,BAEP정상조56례,BAEP 이상조적혈청총담홍소、혈청총담홍소/백단백균현저고우BAEP정상조[(356.50±59.23)μmol/L비(318.70±55.12)μmol/L、(5.02±0.49)×10-3비(4.56±0.43)×10-3],차이유통계학의의(P<0.05);다원회귀분석현시:BAEP이상여혈청총담홍소/백단백밀절상관(r=0.72,P<0.05),이여혈청총담홍소무명현상관성(r=0.19,P>0.05).결론 혈청총담홍소/백단백교혈청총담홍소경능반영고담홍소혈증신생인혈중유리담홍소적수평,가작위평고담홍소신경독성위험인소적지표지일.
Objective To investigate the significance of total bilirubin/albumin in predicting bilirubin neurotoxicity.Methods Eighty-three cases with hyperbilirubinemia who treated from May 2007 to August 2010 were selected,the serum total bilirubin and albumin were detected and total bilirubin/albumin was calculated.According to brainstem auditory evoked potential(BAEP)results,the patients were divided into normal BAEP group and abnormal BAEP group and compared.Results There were 27 cases of abnormal BAEP group and 56 cases of normal BAEP group.Total bilirubin and total bilirubin/albumin in abnormal BAEP group were higher than those in normal BAEP group[(356.50±59.23)μmol/L vs.(318.70±55.12)μmol/L,(5.02±0.49)×10-3 vs.(4.56±0.43)×10-3],the differences were significant (P<0.05).Multiple regression analysis showed:abnormal BAEP was closely related to total bilirubin/albumin(r=0.72,P<0.05),whih abnormal BAEP was not obviously related to total bilirubin(r=0.19,P>0.05).Conclusion Total bilirubin/albumin can reflect serum unconjugated bilirubin level of neonatus with hyperbilirubinemia better than total bilirubin,and it can can be taken as one index to evaluate the risk factors of bilirubin neurotoxicity.
