中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
24期
32-33
,共2页
遗传学%超声检查%胎儿心脏%染色体
遺傳學%超聲檢查%胎兒心髒%染色體
유전학%초성검사%태인심장%염색체
Genetics%Ultrasonography%Fetal heart%Chromosom
目的 探讨超声检查胎儿心脏异常与染色体异常的相关性.方法 回顾性分析3307例产前检查时的胎儿心脏超声检查结果及染色体核型分析结果.分析心脏异常与染色体核型分析结果的相关性.结果 在接受检查的3307例孕妇中,产前超声检查共有194例(5.87％)发现胎儿心脏异常征象,而3113例(94.13％)未发现胎儿心脏异常征象.染色体核型分析共有124例(3.75％)发现胎儿染色体核型异常.心脏异常者染色体异常发生率( 19.59％,38/194)明显高于无心脏异常者染色体异常发生率(2.76％,86/3113),其相对危险度为7.0903,差异有统计学意义(P＜0.01).124例异常染色体核型中,以18-三体(42例)及21-三体(36例)最为常见.结论 胎儿心脏异常者染色体异常发生率比较高,发现心脏异常征象时建议行染色体检查.
目的 探討超聲檢查胎兒心髒異常與染色體異常的相關性.方法 迴顧性分析3307例產前檢查時的胎兒心髒超聲檢查結果及染色體覈型分析結果.分析心髒異常與染色體覈型分析結果的相關性.結果 在接受檢查的3307例孕婦中,產前超聲檢查共有194例(5.87％)髮現胎兒心髒異常徵象,而3113例(94.13％)未髮現胎兒心髒異常徵象.染色體覈型分析共有124例(3.75％)髮現胎兒染色體覈型異常.心髒異常者染色體異常髮生率( 19.59％,38/194)明顯高于無心髒異常者染色體異常髮生率(2.76％,86/3113),其相對危險度為7.0903,差異有統計學意義(P＜0.01).124例異常染色體覈型中,以18-三體(42例)及21-三體(36例)最為常見.結論 胎兒心髒異常者染色體異常髮生率比較高,髮現心髒異常徵象時建議行染色體檢查.
목적 탐토초성검사태인심장이상여염색체이상적상관성.방법 회고성분석3307례산전검사시적태인심장초성검사결과급염색체핵형분석결과.분석심장이상여염색체핵형분석결과적상관성.결과 재접수검사적3307례잉부중,산전초성검사공유194례(5.87％)발현태인심장이상정상,이3113례(94.13％)미발현태인심장이상정상.염색체핵형분석공유124례(3.75％)발현태인염색체핵형이상.심장이상자염색체이상발생솔( 19.59％,38/194)명현고우무심장이상자염색체이상발생솔(2.76％,86/3113),기상대위험도위7.0903,차이유통계학의의(P＜0.01).124례이상염색체핵형중,이18-삼체(42례)급21-삼체(36례)최위상견.결론 태인심장이상자염색체이상발생솔비교고,발현심장이상정상시건의행염색체검사.
Objective To evaluate the correlation between ultrasound detected fetal heart abnormality and chromosomal abnormality.Methods The data of 3307 cases of prenatal fetal echocardiography and karyotype analysis results were retrospectively analyzed.The correlation between heart abnormality and chromsomal abnormality was analyzed.Results In 3307 cases d pregnant women,194cases (5.87％) were found signs of fetal heart abnormality,and 3113 cases (94.13％) were not found any sign of fetal heart abnormality.And 124 cases (3.75％) were found chromosomal abnormality.The rate of chromosomal abnormality in fetus with heart abnormality was higher than that in fetus without heart abnormality [ 19.59％ (38/194) vs.2.76％ ( 86/3113 ),P ＜ 0.01 ],the relative risk ratio was 7.0903.One hundred and twenty-four cases of chromosomal abnormality in the 18-three-body (42 cases) and 21-three-body (36 cases) were the most common.Conclusions Fetal heart abnormality incidence of chromosomal abnormality is high relatively.When the signs of heart abnormality are found,it is suggested that the fetus should examine karyotype analysis.
