CAJ | 학술논문

目的分析男性和女性非小细胞肺癌(non-small cell lung cancer,NSCLC)患者年龄、吸烟史、组织病理学类型、临床表现、临床分期及治疗方案等方面的不同.方法回顾性分析上海长征医院2002年1月至2008年6月收治的921例确诊为肺癌的患者,分析男女NSCLC患者上述各方面的差异,统计学方法选用t检验和x2检验.结果 921例NSCLC患者中,男性647例,占70.2％,女性274例,占29.8％.女性确诊NSCLC早于男性[(57.9±11.4)岁vs(60.9±10.9)岁,P＜0.01],且女性腺癌患者的平均年龄亦低于男性腺癌患者[(57.9±11.6)岁vs(59.8±11.1)岁,P=0.041].男性鳞癌的比例明显高于女性(39.6％ vs 7.7％,P＜0.01),而女性中腺癌比例高于男性(88.7％ vs 55.2％,P＜0.01).在各型NSCLC患者中,男性吸烟的比例均高于女性(鳞癌:86.3％ vs 9.5％,P＜0.01;腺癌:68.1％ vs3.7％,P＜0.01；其他类型NSCLC:76.5％ vs 0.0％,P＜0.01),男性患者咯血的发生率高于女性(32.5％vs 18.6％,P=0.027).结论 NSCLC在男性中更为多发.女性发病早于男性,女性腺癌患者的平均年龄低于男性腺癌患者.男性中鳞癌比例高于女性,而女性中腺癌更为常见.各型NSCLC患者中,男性吸烟的比例均高于女性.
목적 분석남성화녀성비소세포폐암(non-small cell lung cancer,NSCLC)환자년령、흡연사、조직병이학류형、림상표현、림상분기급치료방안등방면적불동.방법 회고성분석상해장정의원2002년1월지2008년6월수치적921례학진위폐암적환자,분석남녀NSCLC환자상술각방면적차이,통계학방법선용t검험화x2검험.결과 921례NSCLC환자중,남성647례,점70.2％,녀성274례,점29.8％.녀성학진NSCLC조우남성[(57.9±11.4)세vs(60.9±10.9)세,P＜0.01],차녀성선암환자적평균년령역저우남성선암환자[(57.9±11.6)세vs(59.8±11.1)세,P=0.041].남성린암적비례명현고우녀성(39.6％ vs 7.7％,P＜0.01),이녀성중선암비례고우남성(88.7％ vs 55.2％,P＜0.01).재각형NSCLC환자중,남성흡연적비례균고우녀성(린암:86.3％ vs 9.5％,P＜0.01;선암:68.1％ vs3.7％,P＜0.01；기타류형NSCLC:76.5％ vs 0.0％,P＜0.01),남성환자각혈적발생솔고우녀성(32.5％vs 18.6％,P=0.027).결론 NSCLC재남성중경위다발.녀성발병조우남성,녀성선암환자적평균년령저우남성선암환자.남성중린암비례고우녀성,이녀성중선암경위상견.각형NSCLC환자중,남성흡연적비례균고우녀성.
Objective To analyze the difference between male and female patients with non-small cell lung cancer (NSCLC) in age,smoking history,histopathologic types,clinical manifestations,staging status and treatment,etc.Methods The data of 921 patients diagnosed with NSCLC in Shanghai Changzheng Hospital from January 2002 to June 2008 were retrospectively analyzed,statistical methods used were t test and x2 test.Results Of 921 patients with NSCLC,647 patients (70.2％) were men and 274 patients (29.8％) were women.Women developed the disease at an earlier age than men [(57.9±11.4) years old vs (60.9± 10.9) years old,P ＜0.01].The female patients with adenocarcinoma were younger than male patients on average [(57.9±11.6) years old vs (59.8±11.1) years old,P =0.041].The proportion of squamous cell carcinoma in male was higher than that in female (39.6％ vs 7.7％,P ＜0.01),but the proportion of adenocarcinoma in men was lower than that in female (55.2％ vs 88.7％,P＜0.01).In all types of NSCLC,men smoked more intensively than women (squamous cell carcinoma:86.3 ％ vs 9.5 ％,P ＜0.01,adenocarcinoma:68.1 ％ vs 3.7 ％,P ＜ 0.01,other types of NSCLC:76.5 ％vs 0.0％,P ＜ 0.01 ).Male patients suffered from hemoptysis more frequently than female patients (32.5％ vs 18.6％,P =0.027).Conclusions NSCLC is more frequently in men than that in women.Women develope the disease at an earlier age than men.In particular,the female patients with adenocarcinoma are younger than male patients on average.Higher proportion of squamous cell carcinoma but less adenocarcinoma is observed in men than in women.In all types of NSCLC,men smoke more intensively than women.