CAJ | 학술논문

目的探讨乙型肝炎病毒(HBV)携带产妇血清HBV DNA含量对胎儿宫内感染的影响,以指导HBV携带者孕期处理. 方法选择经产前血清学检测诊断为HBV携带者的产妇145例,在产妇分娩后采用荧光定量聚合酶链反应技术对同时进行母婴血清HBV DNA检测,并将产妇血清HBV DNA浓度分级,分析产妇血清不同HBV DNA浓度级对新生儿宫内感染情况. 结果 74例血清HBV DNA＜500拷贝/ml的产妇分娩的新生儿中检出HBV DNA阳性者1例(1.4%);30例血清HBV DNA 500～1×106拷贝/ml的产妇分娩的新生儿中检出HBV DNA阳性者1例(3.3%);41例HBV DNA＞1×106拷贝/ml的产妇分娩的新生儿中HBV DNA阳性者3例(7.3%),不同血清HBV DNA浓度的产妇,其新生儿宫内感染率差异无统计学意义(P＞0.05). 结论产妇血清中HBV DNA浓度对胎儿宫内感染率影响不大,孕期抗病毒于预对预防HBV宫内传播意义不大.
목적 탐토을형간염병독(HBV)휴대산부혈청HBV DNA함량대태인궁내감염적영향,이지도HBV휴대자잉기처리. 방법 선택경산전혈청학검측진단위HBV휴대자적산부145례,재산부분면후채용형광정량취합매련반응기술대동시진행모영혈청HBV DNA검측,병장산부혈청HBV DNA농도분급,분석산부혈청불동HBV DNA농도급대신생인궁내감염정황. 결과 74례혈청HBV DNA＜500고패/ml적산부분면적신생인중검출HBV DNA양성자1례(1.4%);30례혈청HBV DNA 500～1×106고패/ml적산부분면적신생인중검출HBV DNA양성자1례(3.3%);41례HBV DNA＞1×106고패/ml적산부분면적신생인중HBV DNA양성자3례(7.3%),불동혈청HBV DNA농도적산부,기신생인궁내감염솔차이무통계학의의(P＞0.05). 결론 산부혈청중HBV DNA농도대태인궁내감염솔영향불대,잉기항병독우예대예방HBV궁내전파의의불대.
Objective To investigate the effect of maternal HBV-DNA concentration on fetus intrauterine infection. Methods HBV DNA in blood samples of 145 HBsAg positive pregnant women and their newborns were detected by fluorescence quantitative polymerase chain reaction(FQ-PCR)technology.This study involved 145 HB-sAg positive pregnant women of three groups:HBV-DNA contents below 500 copies/ml(74 cases),500 ～ 106 copies/ml(30 cases)and ≥ 106 copies/ml(41 cases). Results In the 74 women with HBV-DNA contents below 500 copies/ml ,only one neonates was positive.The corresponding figures for the other two groups were 1 and 3 respectively.Differences between the respective figures were non-significant(P＞0.05). Conclusion The serum HBV DNA contents of pregnant women had little effect on intrauterine infection.Thus the rate of intrauterine HBV infection of fetus can not be reduced by intrapartal anti-viral treatment in pregnant women.