中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2009年
3期
147-151
,共5页
吕玮%戴懿%邱志峰%许少侠%匡季秋%李雁凌%谢静%韩杨%左玲燕%刘正印%邓国华%王爱霞%李太生
呂瑋%戴懿%邱誌峰%許少俠%劻季鞦%李雁凌%謝靜%韓楊%左玲燕%劉正印%鄧國華%王愛霞%李太生
려위%대의%구지봉%허소협%광계추%리안릉%사정%한양%좌령연%류정인%산국화%왕애하%리태생
HIV感染%肝炎,乙型%肝炎,丙型%重叠感染%输血%性传播疾病
HIV感染%肝炎,乙型%肝炎,丙型%重疊感染%輸血%性傳播疾病
HIV감염%간염,을형%간염,병형%중첩감염%수혈%성전파질병
HIV infections%Hepatitis B%Hepatitis C%Super-infection%Blood transfusion%Sexually transmitted diseases
目的 探讨我国经血液(非静脉吸毒者)和性途径传播的HIV感染者合并乙型肝炎和丙型肝炎的状况.方法 回顾性分析2005年1至9月在全国13个研究中心就诊的362例HIV/AIDS患者(静脉吸毒者除外),应用酶联免疫试剂盒分别测定其HBsAg、抗-HBs,HBeAg、抗-Hbe、抗-HBc和抗-HCV.采用t检验和X2检验分别对计量和计数结果进行统计学分析.结果 315例检测血HBV和HCV的患者中,HBsAg阳性14例,占4.4%;抗-HCV阳性158例,占50.2%,抗-HCV阴性157例,占49.8%;HIV、HBV、HCV共感染2例,占0.6%.抗-HCV阳性组中经血液和性传播的比例分别占92%和4%,以血液传播为主;抗-HCV阴性组中经血液和性传播的比例分别占11%和66%,以性传播为主.抗-HCV阳性组的HIV确诊时间、CD4+T淋巴细胞绝对计数、ALT和AST均高于抗-HCV阴性组.两组患者的HBV标志物表达也存在差异,其中抗-HCV阳性组中HBsAg阳性2例,占1.3%,抗-HCV阴性组中HBsAg阳性12例,占7.6%,两组比较差异有统计学意义(X2=7.542,P<0.01).10例HBsAg阳性者进行HBV DNA检测,其中4例阳性,抗-HCV均为阴性.57例抗-HCV阳性患者进行HCV RNA检测,阳性者占63.2%.结论 我国输血和性传播途径的HIV感染合并HBV或HCV感染,以合并HCV感染为主,并多见于经输血感染者.合并HCV感染可加重HIV患者的肝脏损伤,同时也可能存在干扰HBV复制的情况.
目的 探討我國經血液(非靜脈吸毒者)和性途徑傳播的HIV感染者閤併乙型肝炎和丙型肝炎的狀況.方法 迴顧性分析2005年1至9月在全國13箇研究中心就診的362例HIV/AIDS患者(靜脈吸毒者除外),應用酶聯免疫試劑盒分彆測定其HBsAg、抗-HBs,HBeAg、抗-Hbe、抗-HBc和抗-HCV.採用t檢驗和X2檢驗分彆對計量和計數結果進行統計學分析.結果 315例檢測血HBV和HCV的患者中,HBsAg暘性14例,佔4.4%;抗-HCV暘性158例,佔50.2%,抗-HCV陰性157例,佔49.8%;HIV、HBV、HCV共感染2例,佔0.6%.抗-HCV暘性組中經血液和性傳播的比例分彆佔92%和4%,以血液傳播為主;抗-HCV陰性組中經血液和性傳播的比例分彆佔11%和66%,以性傳播為主.抗-HCV暘性組的HIV確診時間、CD4+T淋巴細胞絕對計數、ALT和AST均高于抗-HCV陰性組.兩組患者的HBV標誌物錶達也存在差異,其中抗-HCV暘性組中HBsAg暘性2例,佔1.3%,抗-HCV陰性組中HBsAg暘性12例,佔7.6%,兩組比較差異有統計學意義(X2=7.542,P<0.01).10例HBsAg暘性者進行HBV DNA檢測,其中4例暘性,抗-HCV均為陰性.57例抗-HCV暘性患者進行HCV RNA檢測,暘性者佔63.2%.結論 我國輸血和性傳播途徑的HIV感染閤併HBV或HCV感染,以閤併HCV感染為主,併多見于經輸血感染者.閤併HCV感染可加重HIV患者的肝髒損傷,同時也可能存在榦擾HBV複製的情況.
목적 탐토아국경혈액(비정맥흡독자)화성도경전파적HIV감염자합병을형간염화병형간염적상황.방법 회고성분석2005년1지9월재전국13개연구중심취진적362례HIV/AIDS환자(정맥흡독자제외),응용매련면역시제합분별측정기HBsAg、항-HBs,HBeAg、항-Hbe、항-HBc화항-HCV.채용t검험화X2검험분별대계량화계수결과진행통계학분석.결과 315례검측혈HBV화HCV적환자중,HBsAg양성14례,점4.4%;항-HCV양성158례,점50.2%,항-HCV음성157례,점49.8%;HIV、HBV、HCV공감염2례,점0.6%.항-HCV양성조중경혈액화성전파적비례분별점92%화4%,이혈액전파위주;항-HCV음성조중경혈액화성전파적비례분별점11%화66%,이성전파위주.항-HCV양성조적HIV학진시간、CD4+T림파세포절대계수、ALT화AST균고우항-HCV음성조.량조환자적HBV표지물표체야존재차이,기중항-HCV양성조중HBsAg양성2례,점1.3%,항-HCV음성조중HBsAg양성12례,점7.6%,량조비교차이유통계학의의(X2=7.542,P<0.01).10례HBsAg양성자진행HBV DNA검측,기중4례양성,항-HCV균위음성.57례항-HCV양성환자진행HCV RNA검측,양성자점63.2%.결론 아국수혈화성전파도경적HIV감염합병HBV혹HCV감염,이합병HCV감염위주,병다견우경수혈감염자.합병HCV감염가가중HIV환자적간장손상,동시야가능존재간우HBV복제적정황.
Objective To investigate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV)-positive patients infected by blood (with exception of intravenous drug users) and sexual transmission routes in China. Methods Three hundred and sixty-two cases of HIV positive patients from 13 acquired immune deficiency syndrome (AIDS) centers of China (those intravenous drug users were excluded) were analyzed retrospectively. The serological markers of HBV infection including HBsAg, anti-HBs, HBeAg, anti-Hbe, anti-HBc and anti-HCV antibodies were detected by the chemiluminescence immunoassay(CMIA) or enzyme-linked immunosorbent assay (ELISA). Numeration and measurement data were hnalyzed using chi square test and t test, respectively. Results Both HBV markers and HCV antibody were detected in 315 HIV postitive patients. Among them, fourteen cases were HBsAg positive, with the percentage of 4.4%. One hundred and fifty-eight cases (50. 2%) were anti-HCV antibody postive and 157 cases (49.8%) were negative. Only 2 cases (0.6%) were H1V, HBV, HCV co-infection. In the anti-HCV positive group, the percentage of blood and sexual transmission were 92 % and 4 %, respectively, with a predominant blood transmission; while in the anti-HCV negative group, the percentage of blood and sexual transmission were 11% and 66% respectively, dominating with sexual transmission. The duration of HIV infection, CD4+ T cell absolute numbers, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were all higher in the anti-HCV positive group than those in the anti-HCV negative group. Meanwhile, there were 2 cases (1.3%) of HBsAg positive in the anti-HCV positive group while 12 cases (7.6%) in the anti-HCV negative group, with a statistically significant difference (X2= 7.542, P<0.01). HBV DNA detection was performed in 10 HBsAg positive patients, four of them were HBV DNA positive but all were anti-HCV negative. Fifty-seven patients with anti-HCV positive received HCV RNA detection and 63.2% of them were positive. Conclusions HBV and HCV co-infection exists in HIV-infected Chinese patients, predominantly with HCV co-infection and by blood transmission. HCV infection may aggravate the liver injury of HIV infection and, at the same time, may have some mechanisms to interfere HBV replication.
