CAJ | 학술논문

目的分析表观扩散系数(ADC)随胰腺形态学变化的特征.方法对393例胰腺正常的志愿者行上腹部横断面单次激发平面回波扩散加权成像(SSEP-DWI,扩散敏感因子值为0,500 s/mm2).依据DWI计算出相应的ADC图,测量胰腺头、颈、体及尾部ADC.Kruskal-Wallis秩和检验和Wilcoxon配对符号秩和检验进行统计学分析.结果 393例正常胰腺头、颈、体及尾部ADC平均值分别为(1.52±0.29)×10-3、(1.64±0.34) ×10-3、(1.67 ±0.35)×10-3、(1.58±0.31)×10-3 mm2/s. Kruskal-Wallis 检验结果表明,胰腺不同部位ADC差异具有统计学意义(x2-44.8748,P＜0.0001)；Wilcoxon配对符号秩和检验结果显示,胰腺头与颈部、头与体部、头与尾部、颈与尾部和体与尾部的ADC之间差异均具有统计学意义(P值分别为＜0.0001、＜0.0001、0.0008、0.0062、＜0.0001),而颈与体部ADC差异无统计学意义(P=0.1181).结论正常胰腺ADC随胰腺形态结构不同其差异具有统计学意义,这一特征可为DWI及ADC在胰腺疾病的临床应用及研究提供参考.
목적 분석표관확산계수(ADC)수이선형태학변화적특정.방법 대393례이선정상적지원자행상복부횡단면단차격발평면회파확산가권성상(SSEP-DWI,확산민감인자치위0,500 s/mm2).의거DWI계산출상응적ADC도,측량이선두、경、체급미부ADC.Kruskal-Wallis질화검험화Wilcoxon배대부호질화검험진행통계학분석.결과 393례정상이선두、경、체급미부ADC평균치분별위(1.52±0.29)×10-3、(1.64±0.34) ×10-3、(1.67 ±0.35)×10-3、(1.58±0.31)×10-3 mm2/s. Kruskal-Wallis 검험결과표명,이선불동부위ADC차이구유통계학의의(x2-44.8748,P＜0.0001)；Wilcoxon배대부호질화검험결과현시,이선두여경부、두여체부、두여미부、경여미부화체여미부적ADC지간차이균구유통계학의의(P치분별위＜0.0001、＜0.0001、0.0008、0.0062、＜0.0001),이경여체부ADC차이무통계학의의(P=0.1181).결론 정상이선ADC수이선형태결구불동기차이구유통계학의의,저일특정가위DWI급ADC재이선질병적림상응용급연구제공삼고.
Objective To investigate and determine the apparent diffusion coefficient (ADC) values in different anatomical regions of normal pancreas.Methods A total of 383 volunteers with normal pancreas were included in this study.Single-shot echo planar imaging diffusion weighted imaging (SSEP-DWI; b value =0,500 s/mm2) was employed to determine the ADCs in the head,neck,body and tail parts of the pancreas.Statistical analysis was performed by using Kruskal-Wallis and Wilcoxon signed rank tests.Results The ADCs in the head,neck,body and tail parts of the pancreas was (1.52 ± 0.29) × 10-3,( 1.64 ± 0.34) ×10-3,(1.67±0.35) × 10-3,(1.58 ±0.31) × 10-3 mm2/s,the Kruskal-Wallis test results showed a significant difference of mean ADCs among the different anatomical regions (chi square =44.8748,P ＜0.0001 ).Wilcoxon signed rank test results showed the mean ADCs differed remarkably between the head and neck ( P ＜ 0.0001 ),head and body ( P ＜ 0.0001 ),head and tail ( P =0.0008 ),neck and tail (P =0.0062 ),body and tail (P ＜0.0001),respectively.The mean ADCs between the neck and body was not significantly different (P =0.1181 ).Conclusions The mean ADC values of normal pancreas vary significantly within different anatomical regions,which can serve as a guide for DW1 and ADC in clinical application and research of pancreatic diseases.