CAJ | 학술논문

目的了解中国汉族人群慢性丙型肝炎病毒(HCV)基因型分布规律.方法通过多中心、大样本流行病学调查,经具有国际认证资质的第三方检测机构,采用国际通用的测序方法分析病毒基因型.结果共采集全国不同地区18个研究中心764例(男性384例,女性380例)患者血标本,患者平均年龄(44.9±14.3)岁,平均病程(7.7±7.3)年.最终对740例患者的病毒基因分型进行结果分析.中国慢性丙型肝炎患者共有4种主要基因型和9种亚型,其中以基因1型为主(69.6％),尤其是1b型(68.38％).在较少见的基因6型中,以6a亚型较多.以南、中、北地区划分,基因l型在南北地区的分布差异无统计学意义,基因2a型分布的比例由南向北逐渐增高；较少见的基因3b型、6型主要分布在南方省份.结论中国汉族人群慢性丙型肝炎患者共有4种主要基因型和9种亚型,而少见基因型的分布存在地区差异.
목적 료해중국한족인군만성병형간염병독(HCV)기인형분포규률.방법 통과다중심、대양본류행병학조사,경구유국제인증자질적제삼방검측궤구,채용국제통용적측서방법분석병독기인형.결과 공채집전국불동지구18개연구중심764례(남성384례,녀성380례)환자혈표본,환자평균년령(44.9±14.3)세,평균병정(7.7±7.3)년.최종대740례환자적병독기인분형진행결과분석.중국만성병형간염환자공유4충주요기인형화9충아형,기중이기인1형위주(69.6％),우기시1b형(68.38％).재교소견적기인6형중,이6a아형교다.이남、중、북지구화분,기인l형재남북지구적분포차이무통계학의의,기인2a형분포적비례유남향북축점증고；교소견적기인3b형、6형주요분포재남방성빈.결론 중국한족인군만성병형간염환자공유4충주요기인형화9충아형,이소견기인형적분포존재지구차이.
Objective To understand the distribution of hepatitis C virus (HCV) genotypes in China.Methods A national multi-center,large sample epidemiological survey was carried out and certified by an international third-party testing organization.Internationally accepted method for sequencing analysis of viral genotype was used.Results Patients were those suffered from the 4 major genotypes of chronic hepatitis C,including nine subtypes,which were dominated by genotype 1 (69.6％),with type lb in particular (accounting for 68.38％ ).Among the rare gene-6,we saw more subtypes of 6a.In the south,central,and north areas,there was no significant difference seen between the south and the north areas in the distribution of the genotype 1.However,the rate of gene type 2a increased gradually from south to north.In terms of less common type of gene 3b and gene-6,they were seen mainly in the southern provinces.Conclusion In China,Patients with chronic hepatitis C had 4 HCV genotypes,with 9 subtypes.The rarely seen genotypes 3b and 6 were mainly distributed in the southern provinces.