CAJ | 학술논문

目的:探讨乳清蛋白肽对幼年大鼠体格、长骨发育及血液参数的影响.方法:40只雄性断乳SD大鼠随机分为1个阴性对照组和低(0.225%)、中(0.45%)、高(1.35%)3个乳清蛋白肽干预组,每组10只动物.连续喂养42d,期间每周测量体重和身长一次,计算食物利用率,实验结束时对每只大鼠进行血液常规和生化指标检测,并测定股骨长度、直径、骨矿物质含量和密度.结果:中、高剂量乳清蛋白肽干预组大鼠体重及食物利用率较对照显著增高;高剂量组大鼠股骨近端骨密度及矿物质含量较对照显著增加;乳清蛋白肽干预组大鼠股骨干重、长度和直径较对照有增加趋势,但尚未见统计学差异;中、高剂最组大鼠血肌酐和血尿酸含量较对照组显著降低.结论:一定剂量的乳清蚩白肽能够促进幼年大鼠体格发育和增加长骨矿物质密度.
목적:탐토유청단백태대유년대서체격、장골발육급혈액삼수적영향.방법:40지웅성단유SD대서수궤분위1개음성대조조화저(0.225%)、중(0.45%)、고(1.35%)3개유청단백태간예조,매조10지동물.련속위양42d,기간매주측량체중화신장일차,계산식물이용솔,실험결속시대매지대서진행혈액상규화생화지표검측,병측정고골장도、직경、골광물질함량화밀도.결과:중、고제량유청단백태간예조대서체중급식물이용솔교대조현저증고;고제량조대서고골근단골밀도급광물질함량교대조현저증가;유청단백태간예조대서고골간중、장도화직경교대조유증가추세,단상미견통계학차이;중、고제최조대서혈기항화혈뇨산함량교대조조현저강저.결론:일정제량적유청치백태능구촉진유년대서체격발육화증가장골광물질밀도.
Objective: To investigate the effect of low-molecular-weight whey protein peptides (WPP) on physical development, bone growth and blood parameters in young rats. Methods: Forty male SD rats were randomly divided into 4 groups of 10 rats each, designated as control group, groups with WPP intervention at low, middle and high doses, which were 0.225%, 0.45 % and 1.35 % WPP, respectively. All rats were subjected to feeding for42 consecutive days. Body weight and length of each rat were measured once a week. Blood parameters, femur length and diameter, bone mineral content and bone density of each rat were analyzed at the end of experimental period. Results: WPP intervention at the dose of 0.45 % and 1.35 % resulted in an obvious increase in body weight, femur length, and food utilization rate of rats. Compared to the control group, the bone mineral density and mineral content of proximal femur in rats treated with 1.35 % WPP exhibited a significant increase although no significant impact on femur dry weight, length and diameter. Moreover, the levels of serum creatinine and uric acid in rats treated with 0.45 % and 1.35 % WPP were significantly decreased. Conclusion: WPP could promote growth and development of young rats, and enhance their bone mineral density.