中国医药工业杂志
中國醫藥工業雜誌
중국의약공업잡지
CHINESE JOURNAL OF PHARMACEUTICALS
2010年
1期
55-58
,共4页
胃肠道%特异性生物黏附%凝集素%维生素B_(12)%和B_1%甘露糖%鞭毛蛋白
胃腸道%特異性生物黏附%凝集素%維生素B_(12)%和B_1%甘露糖%鞭毛蛋白
위장도%특이성생물점부%응집소%유생소B_(12)%화B_1%감로당%편모단백
gastrointestinal%specific bioadhesive%lectin%vitamin B_(12) and vitamin B_1%mannose%flagellin
胃肠道特异性生物黏附给药系统是一类兼具靶向特异性和生物黏附功能的新型口服给药制剂,通过以配体修饰载药微粒,实现特异性生物黏附功能.介绍了4种不同配体材料(凝集素、维生素B_(12)和B_1、甘露糖和鞭毛蛋白)介导的 胃肠道特异性生物黏附给药制剂及其作用机制的研究进展.
胃腸道特異性生物黏附給藥繫統是一類兼具靶嚮特異性和生物黏附功能的新型口服給藥製劑,通過以配體脩飾載藥微粒,實現特異性生物黏附功能.介紹瞭4種不同配體材料(凝集素、維生素B_(12)和B_1、甘露糖和鞭毛蛋白)介導的 胃腸道特異性生物黏附給藥製劑及其作用機製的研究進展.
위장도특이성생물점부급약계통시일류겸구파향특이성화생물점부공능적신형구복급약제제,통과이배체수식재약미립,실현특이성생물점부공능.개소료4충불동배체재료(응집소、유생소B_(12)화B_1、감로당화편모단백)개도적 위장도특이성생물점부급약제제급기작용궤제적연구진전.
Gastrointestinal specific bioadhesive drug delivery system with both functions of target specificity and bioadhesion is a novel oral preparation.The drug loaded particles were surface modified with ligands to achieved specific bioadhesive function.The mechanism and research progress of this drug delivery system modified by four kinds of ligands such as lectin,vitamin B_(12) and vitamin B_1,mannose and flagellin are introduced.
