CAJ | 학술논문

原癌基因JUN及FOS的高表达为肺癌频发早期事件,主要系细胞外增殖信号作用的结果.信号转导和转录激活因子蛋白家族是一类具有信号转导和转录调节功能的蛋白质,被认为是细胞增殖促进因子和凋亡抑制因子,参与多种细胞因子、激素和生长因子的信号转导和转录调控,参与细胞的增殖和分化.其主要通过磷酸化活化后,引起JUN和FOS癌基因激活和表达,激活后其蛋白以JUN和FOS异源二聚体或JUN同源二聚体的形式结合到转录激活蛋白1启动子结合位点,诱导癌基因表达,参与细胞恶性转化.
원암기인JUN급FOS적고표체위폐암빈발조기사건,주요계세포외증식신호작용적결과.신호전도화전록격활인자단백가족시일류구유신호전도화전록조절공능적단백질,피인위시세포증식촉진인자화조망억제인자,삼여다충세포인자、격소화생장인자적신호전도화전록조공,삼여세포적증식화분화.기주요통과린산화활화후,인기JUN화FOS암기인격활화표체,격활후기단백이JUN화FOS이원이취체혹JUN동원이취체적형식결합도전록격활단백1계동자결합위점,유도암기인표체,삼여세포악성전화.
Overexpression of JUN and FOS is a usual and early event in lung cancer,which results from the signalization of ecto-multiplication.Signal transducers and activators of transcription are factors of cellular proliferation and apoptosis inhibition,which mediate cytokine signaling.These transcription factors are key regulators of signal transduction and transcriptional control of cytokines,hormones and growth factors and participate in cellular proliferation and differentiation.It provokes oncogene activation and expression of JUN and FOS by phosphorylation,and then activates JUN and FOS to form heterodimers or JUN homodimer,combines with activator protein-1 promotor binding site,induces oncogene expression and participates in cell malignant transformation.