CAJ | 학술논문

阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)是以睡眠过程中反复的上气道狭窄甚至完全闭塞导致频繁发生呼吸暂停为特征的睡眠呼吸障碍性疾病,该疾病与白天嗜睡、肥胖、高血压、缺血性心脏病、心律失常等均有明显的相关性.内源性大麻素系统(endocannabinoid system,ECS)是新近发现的信号系统,由内源性大麻素(endogenous cannabinoids,EC),大麻素受体CB1、CB2及合成、降解EC的酶类共同组成.在体内,ECS有广泛的生理学作用.
조새성수면호흡잠정(obstructive sleep apnea,OSA)시이수면과정중반복적상기도협착심지완전폐새도치빈번발생호흡잠정위특정적수면호흡장애성질병,해질병여백천기수、비반、고혈압、결혈성심장병、심률실상등균유명현적상관성.내원성대마소계통(endocannabinoid system,ECS)시신근발현적신호계통,유내원성대마소(endogenous cannabinoids,EC),대마소수체CB1、CB2급합성、강해EC적매류공동조성.재체내,ECS유엄범적생이학작용.
Obstructive sleep apnea, a common breathing-related sleep disorder, characterized by frequents of apnea lasting seconds to minutes during sleep as a result of airway obstruction,is associated with daytime sleepiness,obesity,hypertension,coronary heart disease,cardiac arrhythmia and so on. The endocannabinoid system is a new endogenous signaling system, which is composed of cannabinoid receptors,endocannabinoids and the molecular machinery required for their synthesis and degradation,and body,the endocannabinoid system is involved in many physiological functions.