国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
15期
1165-1167
,共3页
垂体后叶素%低钠血症%渗透性脱髓鞘综合征
垂體後葉素%低鈉血癥%滲透性脫髓鞘綜閤徵
수체후협소%저납혈증%삼투성탈수초종합정
Pituitrin,Hyponatraemia%Osmotic demyelization syndrome
目的 分析垂体后叶素致渗透性脱髓鞘综合征(osmotic demyelination syndrome,ODS)的临床特征.方法 结合我院收治的1例应用垂体后叶素治疗咯血致ODS的患者的临床资料及国内外文献报道的病例进行综合分析.结果 患者女,43岁,因咯血在外院应用垂体后叶素5d后出现抽搐昏迷,查血钠105 mmol/L,予补钠后急转我院.入院查体肌张力增高,血清钠116 mmol/L,胸部CT示双下肺片状高密度影.头颅CT未见异常,予停用垂体后叶素、控制入水量及补充氯化钠溶液,患者神志渐清醒,但言语含糊,吞咽困难.颅脑MRI示桥脑及桥脑外长T1长T2信号影,考虑ODS.经营养神经及对症治疗后好转.结论 ODS是一种临床少见的继发性脱髓鞘疾病.垂体后叶素引起的ODS与过快纠正低钠血症有关.
目的 分析垂體後葉素緻滲透性脫髓鞘綜閤徵(osmotic demyelination syndrome,ODS)的臨床特徵.方法 結閤我院收治的1例應用垂體後葉素治療咯血緻ODS的患者的臨床資料及國內外文獻報道的病例進行綜閤分析.結果 患者女,43歲,因咯血在外院應用垂體後葉素5d後齣現抽搐昏迷,查血鈉105 mmol/L,予補鈉後急轉我院.入院查體肌張力增高,血清鈉116 mmol/L,胸部CT示雙下肺片狀高密度影.頭顱CT未見異常,予停用垂體後葉素、控製入水量及補充氯化鈉溶液,患者神誌漸清醒,但言語含糊,吞嚥睏難.顱腦MRI示橋腦及橋腦外長T1長T2信號影,攷慮ODS.經營養神經及對癥治療後好轉.結論 ODS是一種臨床少見的繼髮性脫髓鞘疾病.垂體後葉素引起的ODS與過快糾正低鈉血癥有關.
목적 분석수체후협소치삼투성탈수초종합정(osmotic demyelination syndrome,ODS)적림상특정.방법 결합아원수치적1례응용수체후협소치료각혈치ODS적환자적림상자료급국내외문헌보도적병례진행종합분석.결과 환자녀,43세,인각혈재외원응용수체후협소5d후출현추휵혼미,사혈납105 mmol/L,여보납후급전아원.입원사체기장력증고,혈청납116 mmol/L,흉부CT시쌍하폐편상고밀도영.두로CT미견이상,여정용수체후협소、공제입수량급보충록화납용액,환자신지점청성,단언어함호,탄인곤난.로뇌MRI시교뇌급교뇌외장T1장T2신호영,고필ODS.경영양신경급대증치료후호전.결론 ODS시일충림상소견적계발성탈수초질병.수체후협소인기적ODS여과쾌규정저납혈증유관.
Objective To analyze the clinical features of osmotic demyelination syndrome (ODS)induced by pituitrin.Methods The clinical data of one case of pituitrin-related ODS and literatures were comprehensively analyzed.Results The patient,a 43-year-old woman,receiving pituitrin intravenous drip continuously for five days,developed coma and kept twitching her arms and legs.Laboratory testing revealed that blood sodium level was 105 mmol/L.After sodium supplement,the patient came to life,but showed dysarthria,dysphgia.A cranial MRI revealed symmetrical signal abnormities on long T1 and long T2 in her central pontine and extrapontine.The patients' symptoms disappeared mostly after symptomatic treatments.Conclusions ODS induced by pituitrin is highly related to rapid correction of hyponatremia.
