CAJ | 학술논문

目的观察前降支球囊封堵法建立猪急性心肌梗死后左室重构动物模型的效果.结果选取10只健康家养猪,前降支球囊封堵法建立猪急性心肌梗死动物模型.造模术全程心电检测观察心电图动态改变,造模前、造模后1周、3月、6月分别行超声检查和SPECT检查.结果除5只猪造模过程中死亡外,其余5只猪均存活至实验终点,均出现ST段弓背上抬、Q渡形成;随着时间推移,猪急性心肌梗死模型的左室舒张末期内径进行性扩大,心尖室壁厚度进行性变薄,左室舒张末期客积进行性增大,射血分数进行性减低.结论冠脉球囊封堵法可造成理想的急性心肌梗死后左室重构动物模型.
목적 관찰전강지구낭봉도법건립저급성심기경사후좌실중구동물모형적효과.결과 선취10지건강가양저,전강지구낭봉도법건립저급성심기경사동물모형.조모술전정심전검측관찰심전도동태개변,조모전、조모후1주、3월、6월분별행초성검사화SPECT검사.결과 제5지저조모과정중사망외,기여5지저균존활지실험종점,균출현ST단궁배상태、Q도형성;수착시간추이,저급성심기경사모형적좌실서장말기내경진행성확대,심첨실벽후도진행성변박,좌실서장말기객적진행성증대,사혈분수진행성감저.결론 관맥구낭봉도법가조성이상적급성심기경사후좌실중구동물모형.
Objective To investigate the effects of established swine acute myocardial infarction and following ventricular remodeling model by occluding Coronary with balloon. Methods Ten healthy Domestic swine are enrolled. Each swine's left anterior descending coronary artery was occluded for three hours by dilated balloon, and then reperfusion was performed. During the whole course of operation, the electro-cardiogram was monitored. B-ultrasound and single -photon emission computed tomography examination (SPECT) were performed to detect left ventricular end diastolic dimension, left ventricular tip wall thickness, left ventricular end diastolic volume and left ventricula ejection fraction before operation and one week, three month, six month after acute myocardial infarction. Results Five swine died during the period of opera-tion for lack of experience, the remains survived. Electrocardiogram revealed significant ST-elevation and Q-wave formation. B-untrasound and SPECT witnessed deteriorating left ventricular end diastolic dimension expansion, left ventricular tip wall thickness thinning, left ventricular end diastolic volume expansion and left ventricular ejection fraction depression. Conclusions Coronary artery occlusion by balloon can successfully establish acute myocardial infarction and following left ventricular remodeling models.