中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2008年
z1期
46-48
,共3页
前列腺肿瘤%基因%CCND1%基因多态%遗传易感性
前列腺腫瘤%基因%CCND1%基因多態%遺傳易感性
전렬선종류%기인%CCND1%기인다태%유전역감성
Prostatic neoplasms%Gene,CCND1%Genetic polymorphism%Genetic susceptibility
目的 探讨细胞周期蛋白D1(CCND1)基因A870G多态与中国人群前列腺癌(PCa)遗传易感性的关系.方法 采用TaqMan-MGB实时荧光定量PCR法,检测245例PCa与245名非前列腺癌个体对照的CCND1 A870G基因型分布及差异.结果 PCa组和对照组870G等位基因频率分别为47.6%(233/490)和40.8%(200/490),G的PCa发病风险是A的1.31倍(95%CI为1.00～1.72,P=0.054).与AA纯合子相比,AG杂合子的PCa风险增至1.43倍(95%CI为0.89～2.31,P=0.142),而GG纯合子的PCa风险显著增至2.02倍(95%CI为1.07～3.80,P=0.029).将AA、AG和GG视为不同的等级,经趋势Armitage检验,存在等位基因剂量-反应关系(P=0.029).PCa者中,有转移者携带G等位基因(AG、GG基因型)的比例高于无转移者(P=0.014).结论 CCND1 870G增加PCa发病风险,并呈等位基因剂量-反应关系,GG基因型是中国人的PCa遗传易感因素;G等位基因携带可能与Pca转移有关.
目的 探討細胞週期蛋白D1(CCND1)基因A870G多態與中國人群前列腺癌(PCa)遺傳易感性的關繫.方法 採用TaqMan-MGB實時熒光定量PCR法,檢測245例PCa與245名非前列腺癌箇體對照的CCND1 A870G基因型分佈及差異.結果 PCa組和對照組870G等位基因頻率分彆為47.6%(233/490)和40.8%(200/490),G的PCa髮病風險是A的1.31倍(95%CI為1.00～1.72,P=0.054).與AA純閤子相比,AG雜閤子的PCa風險增至1.43倍(95%CI為0.89～2.31,P=0.142),而GG純閤子的PCa風險顯著增至2.02倍(95%CI為1.07～3.80,P=0.029).將AA、AG和GG視為不同的等級,經趨勢Armitage檢驗,存在等位基因劑量-反應關繫(P=0.029).PCa者中,有轉移者攜帶G等位基因(AG、GG基因型)的比例高于無轉移者(P=0.014).結論 CCND1 870G增加PCa髮病風險,併呈等位基因劑量-反應關繫,GG基因型是中國人的PCa遺傳易感因素;G等位基因攜帶可能與Pca轉移有關.
목적 탐토세포주기단백D1(CCND1)기인A870G다태여중국인군전렬선암(PCa)유전역감성적관계.방법 채용TaqMan-MGB실시형광정량PCR법,검측245례PCa여245명비전렬선암개체대조적CCND1 A870G기인형분포급차이.결과 PCa조화대조조870G등위기인빈솔분별위47.6%(233/490)화40.8%(200/490),G적PCa발병풍험시A적1.31배(95%CI위1.00～1.72,P=0.054).여AA순합자상비,AG잡합자적PCa풍험증지1.43배(95%CI위0.89～2.31,P=0.142),이GG순합자적PCa풍험현저증지2.02배(95%CI위1.07～3.80,P=0.029).장AA、AG화GG시위불동적등급,경추세Armitage검험,존재등위기인제량-반응관계(P=0.029).PCa자중,유전이자휴대G등위기인(AG、GG기인형)적비례고우무전이자(P=0.014).결론 CCND1 870G증가PCa발병풍험,병정등위기인제량-반응관계,GG기인형시중국인적PCa유전역감인소;G등위기인휴대가능여Pca전이유관.
Objective To investigate the possible association between the CCND1 A870G polymorphism and susceptibility to prostate cancer(PCa)in a Chinese population.Methods The CCND1 A870G genotypes were determined by TaqMan assays in 245 PCa cases and age-matched 245 controis.Odds ratios(OR)for PCa and 95%confidence intervals(CI)from unconditional logistic regression models were used to evaluate relative risks.Age,a potential PCa risk factor,was included in the logistic regression models as a covariate in the multivariate analyses on genotype and PCa risk.Results The frequencies for G and A alleles were 0.476,0.524 in PCa cases,and 0.408 and 0.592 in controls,respectively.The G allele was marginally significantly associated with the presence of PCa (P=0.054)and had an increased risk for PCa(OR=1.31,95%CI=1.00-1.72)as compared to theA allele.Compared to AA homozygote,AG heterozygote had a 1.43-fold increased risk(95%CI=0.89-2.31,P=0.142),whereas GG homozygote had a significantly higher 2.02-fold increased risk (95%CI=1.07-3.80,P=0.029)of PCa(Armitage's trend test,P=0.029).The G allele(AG or GG genotype)was more frequently found in PCa patients with metastasis than those without metastasis(P=0.014).Conclusion The G allele of CCND1 A870G is associated with the presence of PCa and GG homozygote is potentially one of the genetic risk factors for PCa in Chinese population.The G allele may be associated with the progression of PCa metastasis.
