CAJ | 학술논문

目的探索1-溴丙烷(1-BP)对接触工人神经毒性的剂量-效应关系.方法对国内1-BP生产工厂进行职业卫生现场调查.按1:1比例选取年龄配对的接触组和对照组女工各71人.作业环境中1-BP的浓度用直读式检气管测定,工人的8 h时间加权平均(TWA)浓度用个体采样器测定.对工人进行问卷调查、神经内科检查、神经传导速度检查、振动觉检查、血常规和血液生化检查.根据TWA值和TWA×工龄值将接触工人分为3个剂量组,进行剂量-效应关系分析.使用USEPA BMDS 2.1软件计算1-BP毒作用基准剂量(BMD)和基准剂量下限值(BMDL).结果 TWA-8 h浓度范围为0.35～535.19 mg/m3,(均值14.08 mg/m3).剂量-效应关系分析表明,1-BP接触工人在运动神经远端潜伏期(DL,线性回归系数为0.0666)、双足振动觉(线性回归系数分别为0.157 2和0.193 9)、肌酸激酶水平(线性回归系数为-1.0464)和促甲状腺激素水平(线性回归系数为0.102 4)等指标与1-BP有剂量依赖关系(P<0.05).依据DL资料计算TWA-8 h的BMD值和BMDL值分别为55.55和30.78 mg/m3.结论 1-BP对接触工人具有神经毒性,可引起胫神经DL延长、振动觉下降的剂量依赖性改变.
목적 탐색1-추병완(1-BP)대접촉공인신경독성적제량-효응관계.방법 대국내1-BP생산공엄진행직업위생현장조사.안1:1비례선취년령배대적접촉조화대조조녀공각71인.작업배경중1-BP적농도용직독식검기관측정,공인적8 h시간가권평균(TWA)농도용개체채양기측정.대공인진행문권조사、신경내과검사、신경전도속도검사、진동각검사、혈상규화혈액생화검사.근거TWA치화TWA×공령치장접촉공인분위3개제량조,진행제량-효응관계분석.사용USEPA BMDS 2.1연건계산1-BP독작용기준제량(BMD)화기준제량하한치(BMDL).결과 TWA-8 h농도범위위0.35～535.19 mg/m3,(균치14.08 mg/m3).제량-효응관계분석표명,1-BP접촉공인재운동신경원단잠복기(DL,선성회귀계수위0.0666)、쌍족진동각(선성회귀계수분별위0.157 2화0.193 9)、기산격매수평(선성회귀계수위-1.0464)화촉갑상선격소수평(선성회귀계수위0.102 4)등지표여1-BP유제량의뢰관계(P<0.05).의거DL자료계산TWA-8 h적BMD치화BMDL치분별위55.55화30.78 mg/m3.결론 1-BP대접촉공인구유신경독성,가인기경신경DL연장、진동각하강적제량의뢰성개변.
Objective To explore the dose-effect relationship between 1-bromopropane (1-BP) exposure and health effects in workers. Methods Occupational field investigations were conducted in 1-BP factories. Ambient 1-BP concentrations were detected with detection tube, and the 8 h time-weighted average individual exposure levels (TWA-8 h) were measured by passive sampler. Workers underwent questionnaire survey, neurological examination, nerve conduction velocity examination, vibration sensation test, routine blood test as well as blood biochemical test. According to TWA values or TWA × duration values, workers were divided into three dose groups for dose-effect relationship analysis. USEPA BMDS 2.1 software was applied to calculate 1-BP benchmark dose (BMD) and its 95% lower limit (BMDL). Results The TWA-8h concentrations ranged from 0.35 to 535.19 mg/m3 (geo-mean 14.08 mg/m3). Dose-dependent analysis showed that the motor nerve distal latency (linear regression coefficient was 0.066 6), vibration sensation of toes (linear regression coefficient were 0.157 2 and 0.193 9), creatine kinase (linear regression coefficient was-1.05) and thyroid stimulating hormone levels (linear regression coefficient was 0.102 4) of 1-BP exposed workers changed in a dose-dependent manner (P<0.05). BMD calculation based on DL as 1-BP toxic effect endpoint showed that TWA-8h of the BMD values and BMDL values were 50.55 mg/m3 and 30.78 mg/m3, respectively. Conclusion 1-BP causes dose-dependent changes in tibial nerve DL, vibration sensation, CK and TSH levels.