中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
5期
651-653
,共3页
干燥综合征,原发性%B细胞活化因子%酶联免疫吸附测定
榦燥綜閤徵,原髮性%B細胞活化因子%酶聯免疫吸附測定
간조종합정,원발성%B세포활화인자%매련면역흡부측정
Sj(o)gren's syndrome,primary%B cell activating factor%ELISA
目的 检测原发性干燥综合征(pSS)患者血清中B细胞活化因子受体(BAFF-R)的表达,探讨其在pSS发病中的作用.方法 pSS患者120例,采用酶联免疫吸附法(ELISA)检测血清BAFF-R水平,对照组62例为健康体检者,性别、年龄构成与患者组匹配.分析血清BAFF-R表达与免疫指标、炎性指标及自身抗体的相关性.结果 血清BAFF-R平均水平pSS组为(692.7±536.9)ng/L,对照组为(279.7±186.9)ng/L,pSS组明显高于对照组(P＜0.01).血清BAFF-R水平与免疫球蛋白IgG呈正相关(r=0.429,P＜0.01),与免疫球蛋白IgA、IgM、补体C3、C4、类风湿因子、红细胞沉降率、C反应蛋白无明显相关性.抗核抗体、抗SSA抗体、抗SSB抗体阳性者血清BAFF-R水平高于阴性者.随着抗核抗体滴度的增加,血清BAFF-R水平呈平行增高趋势.结论 pSS患者中BAFF-R表达增高,并与免疫球蛋白定量、自身抗体表达呈相关性.BAFF-R的异常表达参与了pSS的发病.
目的 檢測原髮性榦燥綜閤徵(pSS)患者血清中B細胞活化因子受體(BAFF-R)的錶達,探討其在pSS髮病中的作用.方法 pSS患者120例,採用酶聯免疫吸附法(ELISA)檢測血清BAFF-R水平,對照組62例為健康體檢者,性彆、年齡構成與患者組匹配.分析血清BAFF-R錶達與免疫指標、炎性指標及自身抗體的相關性.結果 血清BAFF-R平均水平pSS組為(692.7±536.9)ng/L,對照組為(279.7±186.9)ng/L,pSS組明顯高于對照組(P＜0.01).血清BAFF-R水平與免疫毬蛋白IgG呈正相關(r=0.429,P＜0.01),與免疫毬蛋白IgA、IgM、補體C3、C4、類風濕因子、紅細胞沉降率、C反應蛋白無明顯相關性.抗覈抗體、抗SSA抗體、抗SSB抗體暘性者血清BAFF-R水平高于陰性者.隨著抗覈抗體滴度的增加,血清BAFF-R水平呈平行增高趨勢.結論 pSS患者中BAFF-R錶達增高,併與免疫毬蛋白定量、自身抗體錶達呈相關性.BAFF-R的異常錶達參與瞭pSS的髮病.
목적 검측원발성간조종합정(pSS)환자혈청중B세포활화인자수체(BAFF-R)적표체,탐토기재pSS발병중적작용.방법 pSS환자120례,채용매련면역흡부법(ELISA)검측혈청BAFF-R수평,대조조62례위건강체검자,성별、년령구성여환자조필배.분석혈청BAFF-R표체여면역지표、염성지표급자신항체적상관성.결과 혈청BAFF-R평균수평pSS조위(692.7±536.9)ng/L,대조조위(279.7±186.9)ng/L,pSS조명현고우대조조(P＜0.01).혈청BAFF-R수평여면역구단백IgG정정상관(r=0.429,P＜0.01),여면역구단백IgA、IgM、보체C3、C4、류풍습인자、홍세포침강솔、C반응단백무명현상관성.항핵항체、항SSA항체、항SSB항체양성자혈청BAFF-R수평고우음성자.수착항핵항체적도적증가,혈청BAFF-R수평정평행증고추세.결론 pSS환자중BAFF-R표체증고,병여면역구단백정량、자신항체표체정상관성.BAFF-R적이상표체삼여료pSS적발병.
Objective To determine the serum levels of B cell activating factor-receptor(BAFF-R)in patients with primary Sj(o)gren's syndrome(pSS)and investigate the role of BAFF-R in the pathogenesis of pSS.Methods The serum concentration of BAFF-R was measured by ELISA in 120 patients with pSS and 62 age-and sex-matched normal controls.Results The median level of serum BAFF-R was(692.7 ± 536.9)ng/L in pSS and (279.7 ± 186.9)ng/L in healthy controls.The serum level of BAFF-R in the pSS was significantly higher than normal controls(P ＜0.01).Higher level of BAFF-R was associated with higher level of IgG(r =0.429,P ＜0.01).Serum level of BAFF-R had no correlation with IgA,IgM,C3,C4,RF,ESR and CRP.BAFF-R level was markedly increased in patients with positive ANA,anti-SSA,anti-SSB antibody compared with those with negative antibody.Conclusion The serum BAFF-R level was significantly elevated and correlated with the level of immunoglobulin and autoantibodies.BAFF-R play certain role in the pathogenesis of pSS.
