CAJ | 학술논문

目的探讨食管癌和贲门癌患者行根治术治疗后的预后影响因素.方法回顾性分析906例行根治术治疗的食管癌和贲门癌患者的临床资料,选择12个可能对患者预后产生影响的特征性临床病理因素,运用Cox比例风险模型进行预后分析.结果 906例患者的1、3、5年累积生存率分别为89.8%、75.4%和71.7%.单因素分析结果显示,年龄、病理类型、病变长度、淋巴结转移数、临床分期、浸润深度、周围器官受侵情况与行根治手术治疗的食管癌和贲门癌患者的预后有关.Cox比例风险模型多因素分析结果显示,病理类型、临床分期、淋巴结转移数、周围器官受侵情况为行根治手术治疗的食管癌和贲门癌患者预后的独立影响因素.结论病理类型、临床分期、淋巴结转移数、周围器官受侵情况为行根治手术治疗的食管癌和贲门癌患者预后的独立影响因素,临床医师在实际工作中可以参考借鉴.
목적 탐토식관암화분문암환자행근치술치료후적예후영향인소.방법 회고성분석906례행근치술치료적식관암화분문암환자적림상자료,선택12개가능대환자예후산생영향적특정성림상병리인소,운용Cox비례풍험모형진행예후분석.결과 906례환자적1、3、5년루적생존솔분별위89.8%、75.4%화71.7%.단인소분석결과현시,년령、병리류형、병변장도、림파결전이수、림상분기、침윤심도、주위기관수침정황여행근치수술치료적식관암화분문암환자적예후유관.Cox비례풍험모형다인소분석결과현시,병리류형、림상분기、림파결전이수、주위기관수침정황위행근치수술치료적식관암화분문암환자예후적독립영향인소.결론 병리류형、림상분기、림파결전이수、주위기관수침정황위행근치수술치료적식관암화분문암환자예후적독립영향인소,림상의사재실제공작중가이삼고차감.
Objective To investigate the factors affecting the long-term survival of patients with carcinoma of esophagus and gastric cardia after curative resection. Methods The clinical data of 906 patients with carcinoma of esophagus and gastric eardia treated by radical resection in 1996-2004 were analyzed retrospectively. Twelve elinicopathologieal factors possibly influencing survival were encoded and assessed by Cox regression analysis. Results The 1-, 3- and 5-year cumulative survival rates were 89.8% , 75.4% and 71.7%, respectively. The univariate analysis showed that age, length of tumor, pathological differentiation, number of metastatic lymph nodes, depth of invasion, involvement of adjacent organs and the TNM stage influenced the prognosis significantly (P <0.01 ). However, multivariate analysis showed that pathologic differentiation, number of metastatic lymph nodes, involvement of adjacent organs and TNM stage were independent prognostic factors ( P < 0.05 ). Conclusion The independent prognostic factors of the patients with carcinoma of esophagus and gastric eardia are pathologic differentiation, TNM stage, number of metastatic lymph nodes, and involvement of adjacent organs. The other factors influencing survival are age, length of tumor and depth of invasion. Furthermore, invasion of adjacent organs suggests worse prognosis, and should be followed-up closely.