西南师范大学学报（自然科学版）
西南師範大學學報（自然科學版）
서남사범대학학보（자연과학판）
JOURNAL OF SOUTHWEST CHINA NORMAL UNIVERSITY
2010年
2期
41-44
,共4页
黄文明%秦玥%李宇%马林%罗群力
黃文明%秦玥%李宇%馬林%囉群力
황문명%진모%리우%마림%라군력
2-溴-1,3-双[2-(5-乙氧基)噁唑基]苯%钳形配体%合成%Robinson-Gabriel合成法
2-溴-1,3-雙[2-(5-乙氧基)噁唑基]苯%鉗形配體%閤成%Robinson-Gabriel閤成法
2-추-1,3-쌍[2-(5-을양기)오서기]분%겸형배체%합성%Robinson-Gabriel합성법
2-bromo-l,3-bis(5-ethoxy-oxazol-2-yl) benzene%pincer ligand%synthesis%Robinson-Gabriel
使用不同种类常规脱水剂实现了钳形配体2-溴-1,3-双[2-(5-乙氧基)噁唑基]苯的合成,但反应条件剧烈,反应时间较长,产率中等,而使用PPh_3-I_2体系来实现这一环化反应时获得了95%的高产率,这一体系不需特殊试剂和苛刻的反应条件温,用于α-酰胺基酯的环化,是Robinson-Gabriel噁唑合成法的有用扩展.
使用不同種類常規脫水劑實現瞭鉗形配體2-溴-1,3-雙[2-(5-乙氧基)噁唑基]苯的閤成,但反應條件劇烈,反應時間較長,產率中等,而使用PPh_3-I_2體繫來實現這一環化反應時穫得瞭95%的高產率,這一體繫不需特殊試劑和苛刻的反應條件溫,用于α-酰胺基酯的環化,是Robinson-Gabriel噁唑閤成法的有用擴展.
사용불동충류상규탈수제실현료겸형배체2-추-1,3-쌍[2-(5-을양기)오서기]분적합성,단반응조건극렬,반응시간교장,산솔중등,이사용PPh_3-I_2체계래실현저일배화반응시획득료95%적고산솔,저일체계불수특수시제화가각적반응조건온,용우α-선알기지적배화,시Robinson-Gabriel오서합성법적유용확전.
Pincer ligand of 2-bromo-l, 3-bis (5-ethoxy-oxazol-2-yl) benzene was synthesized using various common dehydration agent, but these procedures required severe conditions and long reaction time, and just got moderate yields. While as PPh_3 -I_2 system was applied in this reaction, excellent yield of 95% was achieved. This system requires neither uncommon regent nor severe conditions used to cyclize cramido ester, which can serve as the expanding of Robinson-Gabriel oxazole synthesis.
