中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
18期
2751-2753
,共3页
心力衰竭,充血性%培哚普利%美托洛尔
心力衰竭,充血性%培哚普利%美託洛爾
심력쇠갈,충혈성%배타보리%미탁락이
Heart failure,congestive%Perindopril%Metoprolol
目的 观察培哚普利联合美托洛尔治疗老年人慢性心力衰竭的疗效.方法 136例60岁以上慢性心力衰竭患者随机分为两组,对照组(68例)采用洋地黄、利尿剂和硝酸酯类药物等治疗,治疗组(68例)在对照组治疗基础上加服培哚普利和美托洛尔.4～8周为1个疗程.观察两组治疗前后心功能、左室射血分数、六分钟步行试验和血浆脑利钠肽(BNP)改变等.结果 治疗后,治疗组总有效率94.1％,明显高于对照组的70.6％(x2=5.96,P＜0.05);两组治疗后慢性心力衰竭评价指标均较治疗前明显改善(t=2.56、3.23、2.48、2.53、2.79、3.31,均P＜0.05),治疗组较对照组改善更明显(t=2.87、3.12、2.59,均P＜0.05),两组治疗过程中均未发生严重不良反应.结论 培哚普利联合美托洛尔治疗慢性心力衰竭可改善心室重构,提高治疗效果.
目的 觀察培哚普利聯閤美託洛爾治療老年人慢性心力衰竭的療效.方法 136例60歲以上慢性心力衰竭患者隨機分為兩組,對照組(68例)採用洋地黃、利尿劑和硝痠酯類藥物等治療,治療組(68例)在對照組治療基礎上加服培哚普利和美託洛爾.4～8週為1箇療程.觀察兩組治療前後心功能、左室射血分數、六分鐘步行試驗和血漿腦利鈉肽(BNP)改變等.結果 治療後,治療組總有效率94.1％,明顯高于對照組的70.6％(x2=5.96,P＜0.05);兩組治療後慢性心力衰竭評價指標均較治療前明顯改善(t=2.56、3.23、2.48、2.53、2.79、3.31,均P＜0.05),治療組較對照組改善更明顯(t=2.87、3.12、2.59,均P＜0.05),兩組治療過程中均未髮生嚴重不良反應.結論 培哚普利聯閤美託洛爾治療慢性心力衰竭可改善心室重構,提高治療效果.
목적 관찰배타보리연합미탁락이치료노년인만성심력쇠갈적료효.방법 136례60세이상만성심력쇠갈환자수궤분위량조,대조조(68례)채용양지황、이뇨제화초산지류약물등치료,치료조(68례)재대조조치료기출상가복배타보리화미탁락이.4～8주위1개료정.관찰량조치료전후심공능、좌실사혈분수、륙분종보행시험화혈장뇌리납태(BNP)개변등.결과 치료후,치료조총유효솔94.1％,명현고우대조조적70.6％(x2=5.96,P＜0.05);량조치료후만성심력쇠갈평개지표균교치료전명현개선(t=2.56、3.23、2.48、2.53、2.79、3.31,균P＜0.05),치료조교대조조개선경명현(t=2.87、3.12、2.59,균P＜0.05),량조치료과정중균미발생엄중불량반응.결론 배타보리연합미탁락이치료만성심력쇠갈가개선심실중구,제고치료효과.
Objective To evaluate the clinical therapeutic efficacy of perindopril and metoprolol in the treatment of chronic heart failure in old patients( ≥60 years old).Methods 136 old patients( ≥60 years old) with chronic heart failure were randomly divided into the treatment group(n =68) and the control group(n =68).The control group received the routine treatment with digitalis,diuretics and nitroglycerin.The treatment group was given perindopril and metoprolol orally besides the routine treatment.The perindopril was taken orally 2mg per time,and once a day,and gradually raised to maximum does 8mg per time,once a day.The metoprolol was taken orally 25mg per time,twice a day,also gradually raised to maximum dose 25mg per time,twice a day.4-8 weeks were a treatment cycle.The cardiac function,left ventricular ejection fraction ( LVEF),the 6-minute walk and plasma brain natriuretic pep-tide (BNP) were observed before the beginning of the therapy and after,respectively.Results All patients improved their cardiac function,LVEF,plasma BNP and the 6-minute walk significantly after the therapy ( t =2.56,3.23,2.48,2.53,2.79,3.31,all P ＜ 0.05 ).The improvement of the treatment group was more significantly than that of the control group ( t =2.87,3.12,2.59,all P ＜ 0.05 ).The total effective rate of treatment group was 94.1％,significantly higher thar 70.6％ of control group( x2 =5.96,P ＜0.05 ).Conclusion The therapy of perindopril and metoprolol in old patients with chronic heart failure could improve ventvicular remodeling and the effect.
