CAJ | 학술논문

目的探讨含枸橼酸钠的置换液在血液滤过中对凝血功能的影响,以及其使用的安全性.方法健康犬12只分为2组:枸橼酸钠组:使用含1.5mmol/L枸橼酸钠的置换液,在血滤管路静脉端持续补钙;肝素组:使用低分子肝素(20U/kg·h)持续泵入;记录血液滤过前、血液滤过后每2小时的血肌酐、尿素、血气分析、凝血功能(PT、PT%、PT/R、PTINR、APTT、AT3%及Fbg等)的变化.结果两组血浆的肌酐、尿素、血气分析等结果两组无明显差异(P>0.05),血滤滤治疗过程中均未有管路和血滤器堵塞现象;枸橼酸钠组的实验犬体内的PT、FF%、PT/R、PT INR、APTT、AT3%均不延长,纤维蛋白原浓度(Fbg)没有明显下降;与之比较,肝素组体内的PT、PT INR、APTT均有延长(P<0.01).结论枸橼酸盐置换液应用血液滤过治疗时,不会对体内凝血功能及内环境产生不良影响,抗凝效果良好.
목적 탐토함구연산납적치환액재혈액려과중대응혈공능적영향,이급기사용적안전성.방법 건강견12지분위2조:구연산납조:사용함1.5mmol/L구연산납적치환액,재혈려관로정맥단지속보개;간소조:사용저분자간소(20U/kg·h)지속빙입;기록혈액려과전、혈액려과후매2소시적혈기항、뇨소、혈기분석、응혈공능(PT、PT%、PT/R、PTINR、APTT、AT3%급Fbg등)적변화.결과 량조혈장적기항、뇨소、혈기분석등결과 량조무명현차이(P>0.05),혈려려치료과정중균미유관로화혈려기도새현상;구연산납조적실험견체내적PT、FF%、PT/R、PT INR、APTT、AT3%균불연장,섬유단백원농도(Fbg)몰유명현하강;여지비교,간소조체내적PT、PT INR、APTT균유연장(P<0.01).결론 구연산염치환액응용혈액려과치료시,불회대체내응혈공능급내배경산생불량영향,항응효과량호.
Objective To investigate the anticoagulative effect and reliability of sodium citrate substitution fluid during hemofiltration process. Methods 12 healthy hybridize dogs were randomly divided into experimental group and control group.Sodium citrate substitution calcium glyconate (1.5mmol/L) was continuously supplied during the treatment periods in the treatment group, and control group was given low molecular heparin (20U/kg.h). Each group was given hemofiltration, and the blood gas analysis, serum creatinine, blood urea nitrogen (BUN), electrolyte, pmthrombin time (PI), PT%, PT/R, PT INR, activated partial thrombeplastin time(APTF), AT3%, thromboplastin time (TT) and Fbg were examined before hemofiltration and after hemofihration every two hours. Results The results of blood gas analysis, serum creatinine, blood urea nitrogen (BUN) and so on between two groups no significantly difference during the therapeutic periods (P>0.05). Compared with control group, plasma PT, PT INR and APTT in treatment group were significant decrease (P<0.01). Conclusions Therapeutic effects and improved hemorrhagic tendency were achieved in using sodium citrate substitution fluid during hemofiltration.