CAJ | 학술논문

目的研究99Tcm-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(99Tcm-HL91)在缺血心肌中的显像表现,探讨99Tcm-HL91探测缺血但存活心肌的价值.方法 18例已确诊为心肌缺血或心肌梗死的患者均行99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)与99Tcm-HL91心肌灌注显像.在心脏短轴图像上通过感兴趣区技术获取缺血区与正常心肌组织的平均放射性计数,获得99Tcm-MIBI与99Tcm-HL91在局部缺血区与正常心肌组织的放射性比值.结果 10例患者在99Tcm-MIBI显像的放射性稀疏或缺损区而在99Tcm-HL91 SPECT可见到明显的放射性充填;其余8例患者99Tcm-HL91显像心肌摄取不高.结论 99Tcm-HL91可选择性地被存活乏氧心肌摄取,与99Tcm-MIBI SPECT联合应用,可望有效提高检测存活心肌的效能.
목적 연구99Tcm-4,9-이담-3,3,10,10-사갑기십이완-2,11-이동우(99Tcm-HL91)재결혈심기중적현상표현,탐토99Tcm-HL91탐측결혈단존활심기적개치.방법 18례이학진위심기결혈혹심기경사적환자균행99Tcm-갑양기이정기이정(99Tcm-MIBI)여99Tcm-HL91심기관주현상.재심장단축도상상통과감흥취구기술획취결혈구여정상심기조직적평균방사성계수,획득99Tcm-MIBI여99Tcm-HL91재국부결혈구여정상심기조직적방사성비치.결과 10례환자재99Tcm-MIBI현상적방사성희소혹결손구이재99Tcm-HL91 SPECT가견도명현적방사성충전;기여8례환자99Tcm-HL91현상심기섭취불고.결론 99Tcm-HL91가선택성지피존활핍양심기섭취,여99Tcm-MIBI SPECT연합응용,가망유효제고검측존활심기적효능.
Objective To investigate the image characteristic of 99Tcm-4, 9-diaza-3, 3, 10, 10-tetramethyldodecan-2, 11-dione dioxime (99Tcm-HL91) in the ischemic myocardium, thus explore the possibility of 99Tcm-HL91 in assessment of ischemic but viable myocardium. Methods Eighteen patients with cardiac infarction went 99Tcm-sestamibi(99Tcm-MIBI)SPECT and 99Tcm-HL91 SPECT. Average radioactivity of ischemic area and normal area were respectively obtained by region of interest on heart short axis images.The radioactivity ratios of target (ischemic area) -to-non target (normal area) were calculated. Results In 10 patients the positive 99Tcm-HL91 uptake was shown in the defect region of 99Tcm-MIBI images. In the other cases, similar signs have not been found. Conclusions 99Tcm-HL91 may be selectively uptaken by ischemic and hypoxic but viable myocardium. The combination of 99Tcm-MIBI and 99Tcm-HL91 SPECT may be more helpful for accurate evaluation of hypoxic viable myocardium.