CAJ | 학술논문

目的探讨食管-胃结合部腺癌肿瘤分化程度与相关病理学因素的关系.方法对163例根治性手术切除的食管-胃结合部腺癌患者的病理资料进行分析,按照肿瘤分化程度分为分化好和分化差2组,比较2组间N分期、T分期、肿瘤大体类型、脉管癌栓等的病例构成情况以及2组间肿瘤大小和淋巴结转移个数的差异.结果 ①在分化好组,T分期、N分期低者所占比例大(T1和T2约占55.74%,N1和N2约占75.41%),分化差组则以T分期、N分期高者为主(T3和T4约占59.81%,N2和N3约占57.85%),2组间差异均有统计学意义(Z值分别为2.375、4.231,P＜0.05、P＜0.01).②分化好组脉管癌栓发生率为44.26%(27/61),低分化组为63.73%(65/102),2组比较,差异有统计学意义(Z值为2.418,P＜0.05).③2组间肿瘤大体形态类型的比例差异无统计学意义(Z值为0.613,P＞0.05).④分化好组平均肿瘤大小和淋巴结转移个数分别为(4.27±2.00)cm,(4.15±5.27)枚;分化差组分别为(5.87±3.26)cm,(8.80±7.65)枚,2组比较差异均有统计学意义(t值分别为3.90、4.66,P均＜0.01).结论食管-胃结合部腺癌肿瘤分化程度对N分期、T分期、脉管癌栓形成、肿瘤大小及淋巴结转移等多种病理学因素具有显著影响.
목적 탐토식관-위결합부선암종류분화정도여상관병이학인소적관계.방법 대163례근치성수술절제적식관-위결합부선암환자적병리자료진행분석,안조종류분화정도분위분화호화분화차2조,비교2조간N분기、T분기、종류대체류형、맥관암전등적병례구성정황이급2조간종류대소화림파결전이개수적차이.결과 ①재분화호조,T분기、N분기저자소점비례대(T1화T2약점55.74%,N1화N2약점75.41%),분화차조칙이T분기、N분기고자위주(T3화T4약점59.81%,N2화N3약점57.85%),2조간차이균유통계학의의(Z치분별위2.375、4.231,P＜0.05、P＜0.01).②분화호조맥관암전발생솔위44.26%(27/61),저분화조위63.73%(65/102),2조비교,차이유통계학의의(Z치위2.418,P＜0.05).③2조간종류대체형태류형적비례차이무통계학의의(Z치위0.613,P＞0.05).④분화호조평균종류대소화림파결전이개수분별위(4.27±2.00)cm,(4.15±5.27)매;분화차조분별위(5.87±3.26)cm,(8.80±7.65)매,2조비교차이균유통계학의의(t치분별위3.90、4.66,P균＜0.01).결론 식관-위결합부선암종류분화정도대N분기、T분기、맥관암전형성、종류대소급림파결전이등다충병이학인소구유현저영향.
Objective To investigate the relationship between the tumor differentiation and the related pathologic factors in Esophago-gastric junction adenocarcinoma. Methods The pathological data from 163 patients of Esophago-gastric junction adenocarcinoma underwent radical surgical resections were randomly divided two groups (group1: well-differentiated,group2: poor-differentiated). The composition of N stages,T stages,morphological type and vessel carcinoma embolus were compared between the two groups ,respectively. The tumor sizes and the number of metastases lymph nodes were compared between the two groups. Results The cases with lower N stages or T stages in group1 were dominant(T1 and T2:55. 74%,N1 and N2:75.41%). Oppositely,those with higher N stages or T stages were dominant(T3 and T4:59.81%,N1 and N2:57.85%)in group 2. The differences were significant Incidence of vessel carcinoma embolus was 44. 26%(27/61)in group 1 and 63. 73%(65/102)in group 2,with a significant difference. There was no significant difference for morphological type in the two groups. The tumor sizes and the number of metastases lymph was 4. 27 ±2. 00 cm and 4. 15 ±5.27 respectively in group 1 ,and 5. 87 ± 3. 26 cm and 8. 80 ± 7.65 respectively in group 2. The differences were significantly different(Ps ＜ 0. 01).Conclusions The tumor differentiation has significant effect on N stages,T stages,vessel carcinoma embolus,tumor size and the number of metastases lymph nodes in Esophago-gastric junction adenocarcinoma.