中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
3期
301-302
,共2页
欧阳驰%陈晓岚%李石旺%刘科峰%莫艳秀%汤银娟
歐暘馳%陳曉嵐%李石旺%劉科峰%莫豔秀%湯銀娟
구양치%진효람%리석왕%류과봉%막염수%탕은연
吸烟%重金属中毒%DNA损伤
吸煙%重金屬中毒%DNA損傷
흡연%중금속중독%DNA손상
Smoking%Heavy metal toxicity%DNA Lesion
目的 探讨习惯性吸烟对血浆内重金属含量及DNA损伤的影响.方法 随机选择湘南学院94名健康大学三年级男生,其中20名不吸烟者(对照组,C组);74名吸烟者.测定每个大学生血浆内汞、镉、铅及8-羟基脱氧鸟苷(8-OHdG)的含量.吸烟者按照吸烟数量分为E1组(≤20支/周)和E2组(＞20支/周).结果 C组、E1组、E2组血浆中:(1)汞含量分别为(22±16)nmol/L、(36±18)nmol/L、(58±13)nmol/L,3组之间差异有统计学意义(P＜0.01);(2)镉与铅分别为(0.012±0.008)μmol/L与(0.209±0.028)μmol/L、(0.020±0.010)μmol/L与(0.251±0.018)μmol/L、(0.031±0.013)μg/L与(0.272±0.032)μmol/L,3组之间差异均有统计学意义(P＜0.01);(3)8-OHdG分别为(204.2±28.5)μg/L、(354.8±36.1)μg/L、(517.1±19.7)μg/L,3组之间差异有统计学意义(P＜0.01);(4)吸烟者吸烟指数与血浆中镉、铅及8-OHdG的含量均呈正相关(r值分别为0.65、0.52、0.74,P＜0.05),吸烟指数与血浆中汞含量无相关性(r=0.20,P＞0.05).结论 习惯性吸烟能够导致机体重金属的集聚性中毒,并且伴有机体DNA的损伤.随着吸烟量与吸烟时间的累积,这种有害效应的危险性也将显著增大.
目的 探討習慣性吸煙對血漿內重金屬含量及DNA損傷的影響.方法 隨機選擇湘南學院94名健康大學三年級男生,其中20名不吸煙者(對照組,C組);74名吸煙者.測定每箇大學生血漿內汞、鎘、鉛及8-羥基脫氧鳥苷(8-OHdG)的含量.吸煙者按照吸煙數量分為E1組(≤20支/週)和E2組(＞20支/週).結果 C組、E1組、E2組血漿中:(1)汞含量分彆為(22±16)nmol/L、(36±18)nmol/L、(58±13)nmol/L,3組之間差異有統計學意義(P＜0.01);(2)鎘與鉛分彆為(0.012±0.008)μmol/L與(0.209±0.028)μmol/L、(0.020±0.010)μmol/L與(0.251±0.018)μmol/L、(0.031±0.013)μg/L與(0.272±0.032)μmol/L,3組之間差異均有統計學意義(P＜0.01);(3)8-OHdG分彆為(204.2±28.5)μg/L、(354.8±36.1)μg/L、(517.1±19.7)μg/L,3組之間差異有統計學意義(P＜0.01);(4)吸煙者吸煙指數與血漿中鎘、鉛及8-OHdG的含量均呈正相關(r值分彆為0.65、0.52、0.74,P＜0.05),吸煙指數與血漿中汞含量無相關性(r=0.20,P＞0.05).結論 習慣性吸煙能夠導緻機體重金屬的集聚性中毒,併且伴有機體DNA的損傷.隨著吸煙量與吸煙時間的纍積,這種有害效應的危險性也將顯著增大.
목적 탐토습관성흡연대혈장내중금속함량급DNA손상적영향.방법 수궤선택상남학원94명건강대학삼년급남생,기중20명불흡연자(대조조,C조);74명흡연자.측정매개대학생혈장내홍、력、연급8-간기탈양조감(8-OHdG)적함량.흡연자안조흡연수량분위E1조(≤20지/주)화E2조(＞20지/주).결과 C조、E1조、E2조혈장중:(1)홍함량분별위(22±16)nmol/L、(36±18)nmol/L、(58±13)nmol/L,3조지간차이유통계학의의(P＜0.01);(2)력여연분별위(0.012±0.008)μmol/L여(0.209±0.028)μmol/L、(0.020±0.010)μmol/L여(0.251±0.018)μmol/L、(0.031±0.013)μg/L여(0.272±0.032)μmol/L,3조지간차이균유통계학의의(P＜0.01);(3)8-OHdG분별위(204.2±28.5)μg/L、(354.8±36.1)μg/L、(517.1±19.7)μg/L,3조지간차이유통계학의의(P＜0.01);(4)흡연자흡연지수여혈장중력、연급8-OHdG적함량균정정상관(r치분별위0.65、0.52、0.74,P＜0.05),흡연지수여혈장중홍함량무상관성(r=0.20,P＞0.05).결론 습관성흡연능구도치궤체중금속적집취성중독,병차반유궤체DNA적손상.수착흡연량여흡연시간적루적,저충유해효응적위험성야장현저증대.
Objective To investigate the effect of habitual smoking on contents of heavy metals in serum and DNA injury.Methods Ninety-four healthy students were randomly chosen from third-year male students of Xiangnan University,including 74 smokers,20 nonsmokers (C group).The levels of mercury,cadmium,lead and 8-hydroxydeoxyguanosine (8-OHdG) in plasma were detected.Smokers were subdivided into groups E1 ((≤20 cigarettes /week) and E2 (＞20 cigarettes /week).Results In groups C,E1,E2,the mercury levels were 22±16,36±18,58±13 nmol/L,respectively,the difference was significant (P＜0.01);levels of cadmium and lead were 0.012±0.008 and 0.209±0.028,0.020±0.010 and 0.251±0.018,0.031±0.013 and 0.272±0.032 μmol/L,respectively,the difference was significant (P＜0.01);8-OHdG levels were 204.2±28.5,354.8±36.1,517.1±19.7 μg/L,respectively,the difference was significant (P＜0.01);smoking index was positively correlated with serum cadmium,lead,8-OHdG in smokers (r=0.65,0.52,0.74,respectively,P＜0.05),but not with mercury (r=0.20,P＞0.05).Conclusion Habitual smoking can lead to assembled heavy metal poisoning,usually accompanied by DNA lesions.with the accumulation of smoking consumption and time,the risk of adverse effects will be increased obviously.
