CAJ | 학술논문

目的探讨血液病患者在输注红细胞悬液时使用白细胞过滤器预防非溶血性发热性输血反应(NHFTR)的临床效果.方法选取720例次住院血液病患者,随机分为观察组和对照组,观察组采用白细胞过滤器输血,而对照组采用一次性输血器.在输血前、后做常规检查并记录体温、心率、血压、呼吸、血清总胆红素及不良输血反应的发生.结果输血前两组患者均无发热现象,但输血后对照组患者中有35例出现NHFTR,观察组中有5例出现NHFTR,两组比较差异有统计学意义(P＜0.01);输血前后对照组的体温平均变化差与观察组比较差异有统计学意义(P＜0.01);各组输血前后血清总胆红素水平差异均无统计学意义;NHFTR的发生率随输血次数的增加而升高,对照组的发生率升高更加明显,两组差异有统计学意义(P＜0.01).结论白细胞过滤器可有效地预防非溶血性发热性输血反应的发生,确保输血安全.
목적 탐토혈액병환자재수주홍세포현액시사용백세포과려기예방비용혈성발열성수혈반응(NHFTR)적림상효과.방법 선취720례차주원혈액병환자,수궤분위관찰조화대조조,관찰조채용백세포과려기수혈,이대조조채용일차성수혈기.재수혈전、후주상규검사병기록체온、심솔、혈압、호흡、혈청총담홍소급불량수혈반응적발생.결과 수혈전량조환자균무발열현상,단수혈후대조조환자중유35례출현NHFTR,관찰조중유5례출현NHFTR,량조비교차이유통계학의의(P＜0.01);수혈전후대조조적체온평균변화차여관찰조비교차이유통계학의의(P＜0.01);각조수혈전후혈청총담홍소수평차이균무통계학의의;NHFTR적발생솔수수혈차수적증가이승고,대조조적발생솔승고경가명현,량조차이유통계학의의(P＜0.01).결론 백세포과려기가유효지예방비용혈성발열성수혈반응적발생,학보수혈안전.
Objective To investigate the clinical effect of using leukocyte filter to prevent nonhemolytic febrile transfusion reactions(NHFTR) in hematologic patients who were trarisfused erythrocyte suspension. Methods Select 720 inpatients need erythrocyte transfusion and have transfusion records. The patients were randomly divided into investigation group and control group. We made a routine examination and recorded the patients' body temperature, heart rate, blood pressure, respiration rate and transfusion adverse reaction before and after erythrocyte suspeusion transfusion. Results Before blood transfusion, the body temperature of patients between two groups were normal, but after blood transfusion, there were 35 patients with NHFTR in the control group, while only 5 cases in the investigation group which used leucocyte filter, the difference between two groups is significant( P＜0.01 ). The change of the patients' body temperature were compared between two groups before and after transfusion, the changes in the control group was significantly higher than the investigation group( P＜0.01 ). Compared the changes of serum total bilirubin level in all patients before and after transfusion,there was no difference in both groups. The incidence of NHFTR increased with increasing of the transfusion times, but compared with the investigation group,the incidence of the control group was higher significantly(P＜0.01 ). Conclusion Leukocyte filter can prevent the occurring of NHFTR efficiently, enhance the quality of transfusion,guarantee the blood transfusion safety.