CAJ | 학술논문

目的探讨糖耐量低减(IGT)与C反应蛋白(CRP)及颈动脉内膜中层厚度(CAIMT)的关系.方法 108例IGT患者与80例正常糖耐量(NGT)者,采用免疫比浊法测定血清CRP,彩色多普勒超声测定CAIMT.对所有IGT者随访3年,在随访1年半及3年分别重复75 g口服葡萄糖耐量试验(OGTT)及复测各项指标.结果 2例失访,其余106例中IGT组的CRP与CAIMT均明显高于NGT对照组;随访1年半及3年的结果均提示:按血糖转归对IGT者重新划分的IGT组与2型糖尿病(T2DM)组的CRP与CAIMT在初查与复查时分别均明显高于NGT组,CRP在初查与复查时均为T2DM组>IGT组>NGT组,各组间差异有统计学意义;对随访3年时的T2DM组各因素进行相关分析显示:复查FBG、2hPBG分别与初查CRP及CAIMT均呈正相关,CAIMT与血糖、ClIP均呈正相关.多元回归分析提示CRP与血糖、CAIMT均显著相关.结论 CRP水平高的IGT患者更容易转化为糖尿病,在IGT阶段已存在大血管病变的风险.对CRP或CAIMT增高较明显的IGT患者进行抗炎干预具有指导意义.
목적 탐토당내량저감(IGT)여C반응단백(CRP)급경동맥내막중층후도(CAIMT)적관계.방법 108례IGT환자여80례정상당내량(NGT)자,채용면역비탁법측정혈청CRP,채색다보륵초성측정CAIMT.대소유IGT자수방3년,재수방1년반급3년분별중복75 g구복포도당내량시험(OGTT)급복측각항지표.결과 2례실방,기여106례중IGT조적CRP여CAIMT균명현고우NGT대조조;수방1년반급3년적결과 균제시:안혈당전귀대IGT자중신화분적IGT조여2형당뇨병(T2DM)조적CRP여CAIMT재초사여복사시분별균명현고우NGT조,CRP재초사여복사시균위T2DM조>IGT조>NGT조,각조간차이유통계학의의;대수방3년시적T2DM조각인소진행상관분석현시:복사FBG、2hPBG분별여초사CRP급CAIMT균정정상관,CAIMT여혈당、ClIP균정정상관.다원회귀분석제시CRP여혈당、CAIMT균현저상관.결론 CRP수평고적IGT환자경용역전화위당뇨병,재IGT계단이존재대혈관병변적풍험.대CRP혹CAIMT증고교명현적IGT환자진행항염간예구유지도의의.
Objective To investigate the relationship between C-reactive protein (CRP) and carotid intima-media thickness in pa-tients with impaired glucose tolerance (IGT). Methods Senan CRP was measured with immunoturhidimetry and the carotid intima-media thickness (CAIMT) was measured using color Doppler in 108 patients with impaired glucose tolerance (IGT) and 80 subjects with normal glucose tolerance(NGT).Then we observed all IGT patients for 3 years using prospective follow-up method, Oral Glucose tolerance test (OGGT) and every index were measured in follow-up 1.5 year and 3 year. Results 2 objects were lost to follow-up. IGT group showed a significant higher CAIMT and CRP compared with NGT group. After follow-up 1.5 year and 3 year, the patients with impaired glucose toler-ance (IGT) were divided into type 2 diabetes (T2DM) group and IGT group based on the level of blood glucose. Both T2DM group and IGT group showed a significant higher CAIMT and CRP, compared with NGT group. The level of serum CRP of T2DM group was higher than that of IGT group, and the level of serum CRP of IGT group was higher than that of NGT group. There were great differences between each group.Linear correlation showed that the level of blood glucose was positively correlated with CRP and CAIMT in T2DM group after follow-up 3 year. CAIMT was positively correlated with the level of blood glucose and CRP. Mulfivariant stepwise regression showed that CRP was signifi-canfly correlated with the level of blood glucose and CAIMT. Conclusion Inflammation played an important role in the development of dia-betes, and it had great vessels complication. The patients with impaired glucose tolerance, who have high level of CRP, were facilitated to be diabetes, and they were at risk of getting great vessels complication during the phase of impaired glucose tolerance. So it would be helpful to prevent IGT patients with high CRP or CAIMT with anti-inflammatory therapy.