CAJ | 학술논문

皮肤中各种光敏物质或色基吸收紫外线能量后,通过电子传递产生氧自由基,氧自由基参与许多皮肤病理过程.尽管氧自由基可被皮肤自身存在的酶及非酶的抗氧化剂清除,然而过多的氧自由基会导致氧化航氧化不均衡从而产生氧化压力,使皮肤色素改变,DNA等分子氧化破坏,一些酶如基质金属蛋白酶、环氧化酶、一氧化氮合酶、血红素氧化酶等的表达上升.
피부중각충광민물질혹색기흡수자외선능량후,통과전자전체산생양자유기,양자유기삼여허다피부병리과정.진관양자유기가피피부자신존재적매급비매적항양화제청제,연이과다적양자유기회도치양화항양화불균형종이산생양화압력,사피부색소개변,DNA등분자양화파배,일사매여기질금속단백매、배양화매、일양화담합매、혈홍소양화매등적표체상승.
Ultraviolet photons can be absorbed by various photosensitizers(endogenous andexogenous)and chromophores in skin,thereafter stimulate the formation of reactive oxygen species(ROS)through electronic transfer,which are involved in many pathological processes in skin.AIthough ROS atepartly removed by nonenzymic and enzymic antioxidants.residual ROS can cause a pro-oxidant/antioxidantdisequilibrium defined as oxidative stress that subsequently lcads to a change in skin pigmentation,damageto such molecules as DNA.as well as an increment in the expression of matrix metalloproteinases.cyclooxygenases,nitric oxide synthase,heme oxygenase,and so on.