CAJ | 학술논문

目的评价加巴喷丁、羟考酮治疗带状疱疹后神经痛的临床疗效及药物不良反应.方法带状疱疹后遗神经痛(PHN)患者98例,根据随机数字表分为3组:加巴喷丁组34例单纯口服加巴喷丁胶囊;羟考酮组31例单纯口服盐酸羟考酮治疗;联合治疗组33例同时服用加巴喷丁胶囊、羟考酮治疗.治疗1 d、3 d 、7 d、14 d 和 29 d后由专人采用视觉模拟评分(VAS)和睡眠质量评分(QS)分别评估患者的疼痛程度和睡眠质量,记录相关不良反应的发生率.结果与治疗前相比,治疗后各组患者VAS评分明显下降,QS评分显著升高,尤其是联合治疗组患者,其减轻疼痛、改善睡眠的程度和速度均显著优于加巴喷丁组和羟考酮组,其显效率、有效率分别达88.3%和100%.结论加巴喷丁、羟考酮均能显著改善PHN患者的临床症状,而二者联合使用则能更迅速、更有效地控制PHN患者的疼痛,显著改善睡眠,降低药物不良反应,增加患者的治疗信心和依从性,是目前临床治疗该病较为理想的方法,尤其适用于严重的PHN患者.
목적 평개가파분정、간고동치료대상포진후신경통적림상료효급약물불량반응.방법대상포진후유신경통(PHN)환자98례,근거수궤수자표분위3조:가파분정조34례단순구복가파분정효낭;간고동조31례단순구복염산간고동치료;연합치료조33례동시복용가파분정효낭、간고동치료.치료1 d、3 d 、7 d、14 d 화 29 d후유전인채용시각모의평분(VAS)화수면질량평분(QS)분별평고환자적동통정도화수면질량,기록상관불량반응적발생솔.결과 여치료전상비,치료후각조환자VAS평분명현하강,QS평분현저승고,우기시연합치료조환자,기감경동통、개선수면적정도화속도균현저우우가파분정조화간고동조,기현효솔、유효솔분별체88.3%화100%.결론 가파분정、간고동균능현저개선PHN환자적림상증상,이이자연합사용칙능경신속、경유효지공제PHN환자적동통,현저개선수면,강저약물불량반응,증가환자적치료신심화의종성,시목전림상치료해병교위이상적방법,우기괄용우엄중적PHN환자.
Objective To observe the efficacy of gabapentin and oxycontin in postherpetic neuralgia. Methods ninety-eight patients with postherpetic neuralgia (PNN) were randomly allocated to the following 3 groups : group gabapentin group (n=34) ;oxycontin group (n=31) and combination group (n=WK33). The degree of pain and quality of sleep were assessed by a blinded observer using Visual Analogue Scale (VAS) and Quality of Sleep (QS) on the 1st, 3rd, 7th, 14th,28thday after therapy respectively. Results The VAS scores and QS scores of all patients decreased significantly after therapy (P<0.05). Compared with gabapentin group and oxycontin group, the VAS scores and QS scores also reduced markedly in gabapentin plus lxycontin group (P<0.01). The obvious effective rate was 88.9% and the effective rate is 100% in gabapentin plus oxycontin group. Conclusion The combined application of gabapentin and oxyeontin relieves the degree of postherpetic neuralgia and improves the quality of sleep.