中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2009年
13期
916-918
,共3页
王丽娜%刘兰芬%张敬悬%赵贵芳
王麗娜%劉蘭芬%張敬懸%趙貴芳
왕려나%류란분%장경현%조귀방
双相障碍%孤啡肽
雙相障礙%孤啡肽
쌍상장애%고배태
Bipolar Disorder: Nociceptin
目的 探讨血浆孤啡肽(OFQ)水平与双相障碍的关系,为双相障碍的发病机制、诊断等寻找新的生物学指标.方法 筛选47例双相障碍患者(抑郁组21例、躁狂组26例)和31名正常人,应用放射免疫(mA)法分别测定其血浆OFQ浓度,比较病例组与对照组血浆OFQ水平,病例组OFQ含量与各量表总分的相关性.结果 (1)抑郁组OFQ水平高于对照组(t=5.28,P<0.01);躁狂组OFQ水平低于对照组(t=-2.47,P<0.05).差异均具有统计学意义.(2)抑郁组OFQ含量与HAMD、MADRS总分呈显著正相关(r=0.607,P<0.01;r=0.541,P<0.05);躁狂组OFQ含量与BRMS总分呈显著负相关(r=-0.750,P<O.01).结论 血浆OFQ水平的变化可能参与了双相障碍的发生机制并可能反映病情的严重程度,为临床上寻找双相障碍的客观诊断依据及其判断疾病严重程度提供了可能的新的生物学指标.
目的 探討血漿孤啡肽(OFQ)水平與雙相障礙的關繫,為雙相障礙的髮病機製、診斷等尋找新的生物學指標.方法 篩選47例雙相障礙患者(抑鬱組21例、躁狂組26例)和31名正常人,應用放射免疫(mA)法分彆測定其血漿OFQ濃度,比較病例組與對照組血漿OFQ水平,病例組OFQ含量與各量錶總分的相關性.結果 (1)抑鬱組OFQ水平高于對照組(t=5.28,P<0.01);躁狂組OFQ水平低于對照組(t=-2.47,P<0.05).差異均具有統計學意義.(2)抑鬱組OFQ含量與HAMD、MADRS總分呈顯著正相關(r=0.607,P<0.01;r=0.541,P<0.05);躁狂組OFQ含量與BRMS總分呈顯著負相關(r=-0.750,P<O.01).結論 血漿OFQ水平的變化可能參與瞭雙相障礙的髮生機製併可能反映病情的嚴重程度,為臨床上尋找雙相障礙的客觀診斷依據及其判斷疾病嚴重程度提供瞭可能的新的生物學指標.
목적 탐토혈장고배태(OFQ)수평여쌍상장애적관계,위쌍상장애적발병궤제、진단등심조신적생물학지표.방법 사선47례쌍상장애환자(억욱조21례、조광조26례)화31명정상인,응용방사면역(mA)법분별측정기혈장OFQ농도,비교병례조여대조조혈장OFQ수평,병례조OFQ함량여각량표총분적상관성.결과 (1)억욱조OFQ수평고우대조조(t=5.28,P<0.01);조광조OFQ수평저우대조조(t=-2.47,P<0.05).차이균구유통계학의의.(2)억욱조OFQ함량여HAMD、MADRS총분정현저정상관(r=0.607,P<0.01;r=0.541,P<0.05);조광조OFQ함량여BRMS총분정현저부상관(r=-0.750,P<O.01).결론 혈장OFQ수평적변화가능삼여료쌍상장애적발생궤제병가능반영병정적엄중정도,위림상상심조쌍상장애적객관진단의거급기판단질병엄중정도제공료가능적신적생물학지표.
Objective To investigate the plasma levels of nociceptin/orphanin FQ (OGQ) in patients with bipolar depression and bipolar mania and to analyze the relationship of plasma OFQ to bipolar disorders. Methods Peripheral blood samples were collected from 21 patients with bipolar Ⅱ depression (BD group), 26 patients with bipolar Ⅰ mania (BM group), and 31 health adults (control group). The concentrations of plasma OFQ were measured by radioimmunoassay (RIA). The psychological slams was examined by Hamilton Depression Scale (HAMD), Bech-Rafaelsen Mania Rating Scale (BRMS), and Montgomery and Asberg Depression Rating Scale (MADRS). Results The plasma OFQ level of the BD group was (20 ±4) ng/L, signifgcantly higher than that of the control group [(14 ±5) ng/L, t =5.28 ,P < 0. 01], and the OFQ level of the BM group was (11 ± 3) ng/L, significantly lower than that of the control group (t = -2.47 ,P <0.05). There were not significant differences in the plasma OFQ between the males and females in all groups (all P > 0.05). In the BD group the plasma OFQ level was significantly positively correlated with HAMD and MADRS scoreds (r=0. 607,P<0.01;r=0.541 ,P<0. 05). In the BM group the plasma OFQ level was significantly negatively correlated with the BRM score (r = - 0. 750, P < 0.01). Conclusion The changes of plasma OFQ level may play a role in the pathogenesis of bipolar disorder and indicate the severity of disease. Plasma OFQ may be a new biological parameter of bipolar disorder.