CAJ | 학술논문

目的研究老年原发性高血压(EH)血管紧张素Ⅱ型受体(AT1一R)基因A／C1166多态性的特征。方法应用聚合酶链反应一限制性片段长度多态性(PCR—RFLP)技术检测87例汉族老年EH患者和55例正常老年人的AT1－R基因A/C1166多态性分布。结果87例老年EH患者的C1166等位基因频率为0．115，55例正常老年人为0．036，经统计学分析两组间有显著差异(P<0．05)。结论老年EH的患者C1166等位基因频率明显升高，可能为EH发病的危险因素。
목적 연구노년원발성고혈압(EH)혈관긴장소Ⅱ형수체(AT1일R)기인A／C1166다태성적특정。방법 응용취합매련반응일한제성편단장도다태성(PCR—RFLP)기술검측87례한족노년EH환자화55례정상노년인적AT1－R기인A/C1166다태성분포。결과87례노년EH환자적C1166등위기인빈솔위0．115，55례정상노년인위0．036，경통계학분석량조간유현저차이(P<0．05)。결론노년EH적환자C1166등위기인빈솔명현승고，가능위EH발병적위험인소。
Objective This study was to detect the A/C1166 polymorphism of angiotensin Ⅱtype 1 receptor (AT1 － R) gene in the essential hypertensive elder. Methods The A/C1166 polymor-phism of AT1 － R gene was assessed by polymerase chain reaction－ restriction fragment length polymor-phism (PCR－ RFLP) in a case－ control study of 87 EH elders and 55 normotensive elders (NT).Results The genotype frequencies of AA, AC, CC were 0. 805, 0. 161, 0. 034 in EH group and0. 927, 0. 073, 0. 000 in NT group. The frequency of A/C1166 allele was higher in EH group (0. 115)than in NT group (0. 036) (P < 0.05). Conclusion The frequency of C1166 allele was significantlyhigher in EH group than in NT group, which indicated that A/C1166 polymorphism of AT1 － R gene maybe associated with EH in the elderly.