CAJ | 학술논문

目的观察氢溴酸加兰他敏胶囊(GAL)治疗轻、中度阿尔茨海默病(AD)的疗效和不良反应，并与哈伯因片剂相比较。方法 128例AD病人随机分2组，治疗组64例用GAL5mg qid，3d后改为10mg qid，共8周，对照组64例用哈伯因片剂50μg qid，3d后改为1μg qid，共8周。结果治疗组显效率26.56％，有效率75.00％，对照组显效率28.13％，有效率76.56％，2组比较无显著性差异(P＞0.05)；2组副作用发生率分别为39.10％，32.80％，亦无显著性差异(P＞0.05)。结论 GAL治疗轻、中度AD有效。
목적관찰경추산가란타민효낭(GAL)치료경、중도아이자해묵병(AD)적료효화불량반응，병여합백인편제상비교。방법 128례AD병인수궤분2조，치료조64례용GAL5mg qid，3d후개위10mg qid，공8주，대조조64례용합백인편제50μg qid，3d후개위1μg qid，공8주。결과치료조현효솔26.56％，유효솔75.00％，대조조현효솔28.13％，유효솔76.56％，2조비교무현저성차이(P＞0.05)；2조부작용발생솔분별위39.10％，32.80％，역무현저성차이(P＞0.05)。결론 GAL치료경、중도AD유효。
Objective To evaluate the therapeutic effects of galanthamine hydrobromide capule(GAL)which was used to treat Alzheimer disease(AD) and compared to huperzine tablets. Methods 128 patients with mild to moderate AD were recruited,64 patients with GAL,5mg qid for 3 days then 10mg qid for 8 weeks and 64 patients with huperzine tablets,50 μg qid,3 days later 100μg qid for 8 weeks. Results The marked and total effective rates were respectively 26.56% and 75.00% in the GAL group;28.13% and 76.56% in the huperzine tablets group(P＞0.05).The side effect rates were respectively 39.10% and 32.80%(P＞0.05). Conclusions GAL is similar to huperzine tablets in treating mild to moderate AD patients.