CAJ | 학술논문

目的回顾性研究原发性干燥综合征患者并发社区获得性肺炎的危险因素.方法选取2003年1月至2007年12月在四川大学华西医院风湿免疫科住院治疗的原发性干燥综合征患者,对多项观察指标进行单因素分析和logistic回归分析.结果 121例原发干燥综合征患者中有27.3%合并社区获得性肺炎.单因素分析显示年龄、病程、白细胞降低、补体降低、肝功异常、肾功异常、白蛋白降低、高球蛋白、肾小管酸中毒、间质性肺病和免疫抑制剂与原发性干燥综合征合并社区获得性肺炎相关.Logistic回归显示肺间质改变(P=0.022,OR=6.300)、补体降低(P=0.019,OR=5.219),高球蛋白(P=0.021,OR=6.649)是原发性干燥综合征合并社区获得性肺炎的危险因素.结论积极控制原发性干燥综合征的疾病活动.减少危险因素的发生可能是控制原发性干燥综合征合并肺部感染的有效手段.
목적 회고성연구원발성간조종합정환자병발사구획득성폐염적위험인소.방법 선취2003년1월지2007년12월재사천대학화서의원풍습면역과주원치료적원발성간조종합정환자,대다항관찰지표진행단인소분석화logistic회귀분석.결과 121례원발간조종합정환자중유27.3%합병사구획득성폐염.단인소분석현시년령、병정、백세포강저、보체강저、간공이상、신공이상、백단백강저、고구단백、신소관산중독、간질성폐병화면역억제제여원발성간조종합정합병사구획득성폐염상관.Logistic회귀현시폐간질개변(P=0.022,OR=6.300)、보체강저(P=0.019,OR=5.219),고구단백(P=0.021,OR=6.649)시원발성간조종합정합병사구획득성폐염적위험인소.결론 적겁공제원발성간조종합정적질병활동.감소위험인소적발생가능시공제원발성간조종합정합병폐부감염적유효수단.
Objective To investigate the risk factors of community-acquired pneumonia (CAP) in patients with primary Sj(o)gren's syndrome (pSS). Methods The clinical data were collected from 121 inpatients with pSS and tmivariate analysis and logistic regression were conducted to analyze the risk factors of CAP. Results The incidence of CAP in the 121 patients with pSS was 27.3%. Age, disease course, low while blood cells, low complement levels, liver and kidney dysfunction, low albumin, hyperglobulinaemia, renal tubule acidosis, interstitial lung disease (ILD) and immunosuppressive agents were closely related to CAP in these patients. Logistic regression analysis identified ILD, low complement levels and hyperglobulinemia as the risk factors for CAP in patients with pSS. Conclusion Vigorous control ofpSS and minimizing the risk factors may prove effective to lower the incidence of CAP in patients with pSS.