临床麻醉学杂志
臨床痳醉學雜誌
림상마취학잡지
THE JOURNAL OF CLINICAL ANESTHESIOLOGY
2010年
1期
5-7
,共3页
乔世刚%谢红%李华%常留辉%傅志海%王琛
喬世剛%謝紅%李華%常留輝%傅誌海%王琛
교세강%사홍%리화%상류휘%부지해%왕침
雷米芬太尼%拔管期心血管反应
雷米芬太尼%拔管期心血管反應
뢰미분태니%발관기심혈관반응
Remifentanil%Cardiovascular response to extubation
目的 探讨雷米芬太尼靶控输注(TCI)拔管期有效抑制心血管反应的半数有效血浆浓度(EC_(50)).方法 择期全麻下行腹腔镜胆囊切除术(LC)成人患者40例,按照序贯法TCI血浆浓度分别为0.6、0.8、1.0、1.2和1.4 ng/ml的雷米芬太尼,初始靶浓度为1.0 ng/ml,若患者拔管时SBP高于基础值的20%或HR快于100次/分,或拔管时出现呛咳、躁动,则下一例患者采用高一级浓度的雷米芬太尼TCI;反之则采用低一级浓度的雷米芬太尼TCI.计算全麻拔管期有效抑制心血管反应的雷米芬太尼EC_(50)及其95%可信区间(CI).结果 TCI雷米芬太尼抑制心血管反应的EC_(50)为1.03 ng/ml,其95%CI为0.97~1.09 ng/ml.结论 LC全麻拔管期有效抑制心血管反应的雷米芬太尼EC_(50)为1.03 ng/ml.
目的 探討雷米芬太尼靶控輸註(TCI)拔管期有效抑製心血管反應的半數有效血漿濃度(EC_(50)).方法 擇期全痳下行腹腔鏡膽囊切除術(LC)成人患者40例,按照序貫法TCI血漿濃度分彆為0.6、0.8、1.0、1.2和1.4 ng/ml的雷米芬太尼,初始靶濃度為1.0 ng/ml,若患者拔管時SBP高于基礎值的20%或HR快于100次/分,或拔管時齣現嗆咳、躁動,則下一例患者採用高一級濃度的雷米芬太尼TCI;反之則採用低一級濃度的雷米芬太尼TCI.計算全痳拔管期有效抑製心血管反應的雷米芬太尼EC_(50)及其95%可信區間(CI).結果 TCI雷米芬太尼抑製心血管反應的EC_(50)為1.03 ng/ml,其95%CI為0.97~1.09 ng/ml.結論 LC全痳拔管期有效抑製心血管反應的雷米芬太尼EC_(50)為1.03 ng/ml.
목적 탐토뢰미분태니파공수주(TCI)발관기유효억제심혈관반응적반수유효혈장농도(EC_(50)).방법 택기전마하행복강경담낭절제술(LC)성인환자40례,안조서관법TCI혈장농도분별위0.6、0.8、1.0、1.2화1.4 ng/ml적뢰미분태니,초시파농도위1.0 ng/ml,약환자발관시SBP고우기출치적20%혹HR쾌우100차/분,혹발관시출현창해、조동,칙하일례환자채용고일급농도적뢰미분태니TCI;반지칙채용저일급농도적뢰미분태니TCI.계산전마발관기유효억제심혈관반응적뢰미분태니EC_(50)급기95%가신구간(CI).결과 TCI뢰미분태니억제심혈관반응적EC_(50)위1.03 ng/ml,기95%CI위0.97~1.09 ng/ml.결론 LC전마발관기유효억제심혈관반응적뢰미분태니EC_(50)위1.03 ng/ml.
Objective To determine the half-effective target plasma concentration (EC_(50)) of remifentanil TCI for attenuating cardiovascular response to extubation. Methods Forty patients aged 18 to 60 years old undergoing selective laparoscopic cholecystectomy(LC) under general anesthesia By up-and-down sequential trial, remifentanil in the target plasma concentrations of 0. 6,0. 8,1.0, 1.2, and 1.4 ng/ml was infused. The initial plasma concentration was set at 1.0 ng/ml, a higher or lower TC1 dose was selected if SBP or HR changed by more than 20% deviation from the baseline. EC_(50) of remifentanil and its 95% confidence interval were calculated. Results The EC_(50) of remifentanil TCI for attenuating cardiovascular response was 1.03 ng/ml, 95% confidence interval ranged from 0. 97-1.09 ng/ml. Conclusion The EC_(50) of remifentanil TCI was 1.03 ng/ml for attenuating cardiovascular response to extubation in patients undergoing LC.