CAJ | 학술논문

目的:研究信号转导与转录活化因子3(signal transducers and activators of transcription 3,STAT3)在人喉鳞状细胞癌(简称喉癌)组织中的表达,探讨其在喉癌发生发展中的作用. 方法:应用免疫组化SP法检测12例正常喉组织及38例喉癌组织中STAT3的阳性表达情况. 结果:STAT3阳性表达主要定位于细胞浆,STAT3蛋白在喉癌组织中的阳性细胞表达率(44.05%±13.82%)高于正常喉黏膜组织(6.40%±1.77%),其差异具有统计学意义(P<0.01).中、低分化伴颈部淋巴结转移的喉癌组织中STAT3阳性细胞表达率显著高于高分化、无颈部淋巴结转移的喉癌组织(P<0.05). 结论:STAT3在喉癌组织的高表达可能与喉癌的发生、发展密切相关.
목적:연구신호전도여전록활화인자3(signal transducers and activators of transcription 3,STAT3)재인후린상세포암(간칭후암)조직중적표체,탐토기재후암발생발전중적작용. 방법:응용면역조화SP법검측12례정상후조직급38례후암조직중STAT3적양성표체정황. 결과:STAT3양성표체주요정위우세포장,STAT3단백재후암조직중적양성세포표체솔(44.05%±13.82%)고우정상후점막조직(6.40%±1.77%),기차이구유통계학의의(P<0.01).중、저분화반경부림파결전이적후암조직중STAT3양성세포표체솔현저고우고분화、무경부림파결전이적후암조직(P<0.05). 결론:STAT3재후암조직적고표체가능여후암적발생、발전밀절상관.
OBJECTIVE: To explore the expression and significance of signal transducers and activators of transcription 3(STAT3) in laryngeal squamous cell cancer. METHODS: Immunohistochemical technique was used to examine expression of STAT3 in 12 normal tissues and 38 laryngeal cancer. RESULTS: Positive staining of STAT3 was localized in the cytoplasm. The positive rate of STAT3 in 38 laryngeal cancer was significantly higher than those in 12 normal tissues (P < 0.01) . Overexpression of STAT3 protein was tested in those cancers with lymph nodes metastasis (P <0.05), and had a close relationship with histological grades(P < 0.05) . CONCLUSION: Overexpression of STAT3 might have a close correlation with the development of laryngeal squamous cell carcinoma.