中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2010年
4期
248-250,281
,共4页
张萌萌%李强%宋玉庭%吴乃宝%张艳会%张大伟
張萌萌%李彊%宋玉庭%吳迺寶%張豔會%張大偉
장맹맹%리강%송옥정%오내보%장염회%장대위
骨代谢指标%骨密度%相关性%骨质疏松
骨代謝指標%骨密度%相關性%骨質疏鬆
골대사지표%골밀도%상관성%골질소송
Bone metabolism index%Bone mineral density%Correlation%Osteoporosis
目的 研究抗酒石酸酸性磷酸酶(TRACP)、Ⅰ型胶原C端肽(CTX-1)、骨特异性碱性磷酸酶(BALP)、降钙素(CT)、骨钙素(BGP)、甲状旁腺激素(PTH)、25-羟基维生素D_3(25(OH)D_3)与前臂远端骨密度相关关系.方法 采用美国Osteometer Medi Tech公司生产的DTX-200型骨密度仪检测受试者非受力侧前臂桡、尺骨远端三分之一处骨密度(BMD);采用美国贝克曼公司全自动化学发光免疫分析仪、美国Thermo公司酶标免疫分析仪检测骨代谢指标;将791例受试者检测结果 按不同性别,每5岁为一个年龄段分组;应用SPSS 13.0分析软件进行统计分析.结果 35~49岁人群TRACP、CTX-1、BALP、BGP等指标性别间不存在差异;50~79岁人群性别间差异显著,女性高于男性.TRACP、CTX-1与BMD负相关;女性BALP、BGP在50~64年龄段明显升高,与BMD负相关,65岁以后开始下降.25(OH)D_3与BMD正相关;CT降低出现在65~79岁年龄段,与BMD显著正相关.结论 骨代谢指标测定是监测骨量变化及骨质疏松早期诊断的重要技术手段.
目的 研究抗酒石痠痠性燐痠酶(TRACP)、Ⅰ型膠原C耑肽(CTX-1)、骨特異性堿性燐痠酶(BALP)、降鈣素(CT)、骨鈣素(BGP)、甲狀徬腺激素(PTH)、25-羥基維生素D_3(25(OH)D_3)與前臂遠耑骨密度相關關繫.方法 採用美國Osteometer Medi Tech公司生產的DTX-200型骨密度儀檢測受試者非受力側前臂橈、呎骨遠耑三分之一處骨密度(BMD);採用美國貝剋曼公司全自動化學髮光免疫分析儀、美國Thermo公司酶標免疫分析儀檢測骨代謝指標;將791例受試者檢測結果 按不同性彆,每5歲為一箇年齡段分組;應用SPSS 13.0分析軟件進行統計分析.結果 35~49歲人群TRACP、CTX-1、BALP、BGP等指標性彆間不存在差異;50~79歲人群性彆間差異顯著,女性高于男性.TRACP、CTX-1與BMD負相關;女性BALP、BGP在50~64年齡段明顯升高,與BMD負相關,65歲以後開始下降.25(OH)D_3與BMD正相關;CT降低齣現在65~79歲年齡段,與BMD顯著正相關.結論 骨代謝指標測定是鑑測骨量變化及骨質疏鬆早期診斷的重要技術手段.
목적 연구항주석산산성린산매(TRACP)、Ⅰ형효원C단태(CTX-1)、골특이성감성린산매(BALP)、강개소(CT)、골개소(BGP)、갑상방선격소(PTH)、25-간기유생소D_3(25(OH)D_3)여전비원단골밀도상관관계.방법 채용미국Osteometer Medi Tech공사생산적DTX-200형골밀도의검측수시자비수력측전비뇨、척골원단삼분지일처골밀도(BMD);채용미국패극만공사전자동화학발광면역분석의、미국Thermo공사매표면역분석의검측골대사지표;장791례수시자검측결과 안불동성별,매5세위일개년령단분조;응용SPSS 13.0분석연건진행통계분석.결과 35~49세인군TRACP、CTX-1、BALP、BGP등지표성별간불존재차이;50~79세인군성별간차이현저,녀성고우남성.TRACP、CTX-1여BMD부상관;녀성BALP、BGP재50~64년령단명현승고,여BMD부상관,65세이후개시하강.25(OH)D_3여BMD정상관;CT강저출현재65~79세년령단,여BMD현저정상관.결론 골대사지표측정시감측골량변화급골질소송조기진단적중요기술수단.
Objective To study the relationships between Bone mineral density(BMD)and serum levels of bone metabolism index including Tartrate-resistant acid phosphatase(TRACP),Collagen type Ⅰ carboxyterminal peptide(CTX-1),Bone alkaline phosphotase(BALP),Calcitonin(CT),Bone Gla protein(BGP),Paratyroid hormone(PTH)and 25(OH)Vitamin D_3(25(OH)D_3).Methods BMD at the one-third of distal Radius and ulna of non-dominant forearm was measured using DTX-200 detector made by American Osteometer Medi Tech Corporation:The bone metabolism index were measured by full-auto chemiluminescence analyzer(USA Beckmancoulter) and full-auto micro plate eia analyzer (USA Thermo).The 791 persons was didived into several groups by every five years.and then applied sofware SPSS 13.0 to statistics data.Results The bone metabolism index such as TRACP,CTX-1,BALP,BGP were not statistically significant at gender among the age groups from 35 to 49 years old,but did among the age groups from 50 t0 79 years old and the data of them in female was higher than them in male.The measure values of TRACP and CTX-1 were negative correlated with BMD;The measure values of BALP,BGP at the age groups from 50 to 64 yaers old was increased in female and were negative correlated with BMD,however,the measure values of them were decreased from 65 years old.The measure values of 25(OH)D_3 was positive correlated with BMD;The measure values of CT was decreased in the age groups from 65 to 79 years old,and was positive correlated with BMD.Conclusion The test of bone metabolism index provided a significant technical method for monitoring bone mass and the earlier diagnosis of osteoporosis.