CAJ | 학술논문

恶性肿瘤是危害人类健康的主要疾病之一,确切的发病机制尚不清楚,但可以肯定的是,其形成具有多因素、多步骤的特点,涉及一系列原癌基因异常的激活以及抑癌基因突变导致的失活,从而引起一些信号转导通路的异常.近年来,通过对Hedgehog(Hh)信号通路的研究显示,Hh基因编码一系列分泌型信号蛋白,对胚胎发育过程中的细胞分化和增生具有重要作用,Hh信号通路的异常活化在恶性肿瘤的发生发展过程中起了重要作用.信号蛋白Hh的信号通路至少包括:patched(Ptch)、smoothened(Smo)、fused(Fu)、suppressor of fused (SuFu),costaⅠ-2(Cos-2)以及cubitus interruptus(Ci)等.本文就Hh基因家族的功能及其与多种人类恶性肿瘤发生相关的机制作一简要综述.
악성종류시위해인류건강적주요질병지일,학절적발병궤제상불청초,단가이긍정적시,기형성구유다인소、다보취적특점,섭급일계렬원암기인이상적격활이급억암기인돌변도치적실활,종이인기일사신호전도통로적이상.근년래,통과대Hedgehog(Hh)신호통로적연구현시,Hh기인편마일계렬분비형신호단백,대배태발육과정중적세포분화화증생구유중요작용,Hh신호통로적이상활화재악성종류적발생발전과정중기료중요작용.신호단백Hh적신호통로지소포괄:patched(Ptch)、smoothened(Smo)、fused(Fu)、suppressor of fused (SuFu),costaⅠ-2(Cos-2)이급cubitus interruptus(Ci)등.본문취Hh기인가족적공능급기여다충인류악성종류발생상관적궤제작일간요종술.
As one of the most major disease,malignant tumor is harmful to human health.Althought it' s exact pathogenesis is still not clear,it is certainly that the formation of cancer is typical of containing many factors and having gone through many steps.Resulting from the abnormal activation of a series of proto-oncogene as well as the inactivation caused by many anti-oncogene mutation,some signal pathways work abnormally.In recent years,the study of Hedgehog ( Hh),as the signal pathway,shows that Hh encodes a series of secreted signaling protein,having an important effect on the differentiation and proliferation of cells in the process of embryogenesis.The occurrence of abnormal activation of Hh signaling pathway plays a significant role in the process of tumorigenesis.Signal paths of Hh signaling protein include as much as following at least:patched(Ptch),smoothened (Smo),fused (Fu),suppressor of fused (SuFu),costaⅠ-2 (Cos)-2 and cubitus interruptus (Ci) and so on.In this paper,the function of Hh genetic family and the mechanism of its relation to many kinds of human cancers will be givien a brief overview.