CAJ | 학술논문

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆神经肽Y(NPY)浓度与患者睡前及晨起血压水平的相关性.方法分组:肥胖OSAHS患者32例(OSAHS组)、非OSAHS肥胖者26例(单纯肥胖组)和体质量正常的健康成人27名(正常对照组).其中OSAHS组和单纯肥胖组接受多导睡眠仪(PSG)监测.血浆NPY的浓度采用酶联免疫吸附试验(ELISA)法测定.结果 OSAHS组血浆NPY浓度显著高于单纯肥胖组(P＜0.05)及正常对照组(P＜0.01).OSAHS患者睡前舒张压、晨起收缩压及舒张压比单纯肥胖组明显升高,差异有统计学意义.相关分析显示,OSAH S组血浆NPY浓度与患者睡前舒张压、晨起收缩压及舒张压呈正相关(P值分别为0.049、0.017、0.006).结论 OSAHS组NPY水平升高,NPY对OSAHS患者血压尤其晨起血压升高起到一定促进作用.
목적 탐토조새성수면호흡잠정저통기종합정(OSAHS)환자혈장신경태Y(NPY)농도여환자수전급신기혈압수평적상관성.방법 분조:비반OSAHS환자32례(OSAHS조)、비OSAHS비반자26례(단순비반조)화체질량정상적건강성인27명(정상대조조).기중OSAHS조화단순비반조접수다도수면의(PSG)감측.혈장NPY적농도채용매련면역흡부시험(ELISA)법측정.결과 OSAHS조혈장NPY농도현저고우단순비반조(P＜0.05)급정상대조조(P＜0.01).OSAHS환자수전서장압、신기수축압급서장압비단순비반조명현승고,차이유통계학의의.상관분석현시,OSAH S조혈장NPY농도여환자수전서장압、신기수축압급서장압정정상관(P치분별위0.049、0.017、0.006).결론 OSAHS조NPY수평승고,NPY대OSAHS환자혈압우기신기혈압승고기도일정촉진작용.
Objective To explore the correlation of plasma concentration of neuropeptide Y (NPY)in patients of obstructive sleep apnea-hypopnea syndrome (OSAHS) with before sleep and morning blood pressure.Methods The study set three group,32 obese OSAHS patients (OSAHS group),26 obese adults without OSAHS (simple obesity group) and 27 healthy adults (normal controls group).Polysomnography (PSG) was performed in OSAHS group and simple obesity group.The concentration of plasma NPY were detected by enzyme-linked immunosorbent (ELISA).Results Plasma NPY concentration in OSAHS group was significantly higher than in the simple obesity group ( P ＜0.05) and the control group ( P ＜0.01) respectively.Plasma NPY level in the OSAHS group correlated positively with DBP before sleep,morning SBP and DBP (P as 0.049,0.017,0.006,respectively).Conclusions The plasma NPY in OSAHS group and simple obesity group elevated.NPY might play a promoting role for elevated blood pressure in particular morning blood pressure of OSAHS patients.