CAJ | 학술논문

目的了解我国氯喹加伯氨喹八日疗法对中缅边境地区间日疟患者的治疗效果.方法便于追踪、满足纳入条件的单纯间日疟患者且同意参加本次研究者被纳入观察.成人给予氯喹口服总剂量1 200 mg(基质)/3 d,D0给予600 mg,D1、D2分别给予300 mg;联合伯氨喹口服总剂量(基质)180 mg/8 d,D0-D7每次的口服剂量是22.5 mg;患者被纳入观察的第1天作为D0,且在D0、D1、D2、D3、D7、D14、D21和D28检查血涂片.结果共67人纳入本次观察,其中57人完成D28随访观察.原虫无性体平均转阴时间为41.05±14.01 h、配子体平均转阴时间为20.25±12.86 h、原虫平均退热时间为26.29±10.72 h,至D28仍无原虫再现,57例患者临床及原虫治疗成功.结论中缅边境地区的间日疟患者对我国的八日疗法敏感.
목적 료해아국록규가백안규팔일요법대중면변경지구간일학환자적치료효과.방법 편우추종、만족납입조건적단순간일학환자차동의삼가본차연구자피납입관찰.성인급여록규구복총제량1 200 mg(기질)/3 d,D0급여600 mg,D1、D2분별급여300 mg;연합백안규구복총제량(기질)180 mg/8 d,D0-D7매차적구복제량시22.5 mg;환자피납입관찰적제1천작위D0,차재D0、D1、D2、D3、D7、D14、D21화D28검사혈도편.결과 공67인납입본차관찰,기중57인완성D28수방관찰.원충무성체평균전음시간위41.05±14.01 h、배자체평균전음시간위20.25±12.86 h、원충평균퇴열시간위26.29±10.72 h,지D28잉무원충재현,57례환자림상급원충치료성공.결론 중면변경지구적간일학환자대아국적팔일요법민감.
Objective To evaluate the efficacy of 8-day regimen of chloroquine-primaquine for treatment of Plasmodium vivax malaria at China-Myanmar border area. Methods To facilitate tracking, the uncomplicated vivax malaria infected patients who met the inclusion requirements and agreed to participate in the study were enrolled. Adults were given chloroquine orally at a total dose of 1 200 mg divided into 3 d as 600 mg at D0 followed by 300 mg daily at D1 and D2, combined with primaquine orally at a total dose of 180 mg(base)divided into 8 d as 22.5 mg/d from D0 to D7. The first day of patient enrollement was regarded as D0 and blood smear were examined on D0, D1, D2, D3, D7, D14, D21 and D28. Results Total of 67 patientswere enrolled for the study and 57 of them completed the clinical observation of 28 days. The mean asexual parasite clearance time was 41.05 ± 14.01 h, and the mean gametocyte clearance time was 20.25 ± 12.86 h, the mean fever clearance time was 26.29 ± 10.72 h. No recurrence of the parasites occured till D28. All 57 patients were cured clinically and parasitologically. Conclusion The patients infected with Plasmodium vivax malaria at China-Myanmar border areas are sensitive to 8-day regimen of chloroquine-primaquine.