CAJ | 학술논문

目的探讨高血压脑出血(HCH)患者血清瘦素水平变化及其与胰岛素抵抗(IR)的关系.方法采用氧化酶法和放免法分别测定57例高血压脑出血(A组)、50例高血压(B组)、41例健康查体者(C组)空腹胰岛素(FBI)、空腹血糖(FBG)及血清瘦素(LP)值,计算胰岛素敏感指数(ISI).结果 A组较B组和C组:FNS、LP水平显著增高(P＜0.05),而ISI水平显著降低(P＜0.05).相关分析发现,A组血清LP水平与ISI呈显著负相关,与FNS呈显著正相关.结论 A组LP水平增高,且与IR并存,二者可能共同参与HCH的发生.
목적 탐토고혈압뇌출혈(HCH)환자혈청수소수평변화급기여이도소저항(IR)적관계.방법 채용양화매법화방면법분별측정57례고혈압뇌출혈(A조)、50례고혈압(B조)、41례건강사체자(C조)공복이도소(FBI)、공복혈당(FBG)급혈청수소(LP)치,계산이도소민감지수(ISI).결과 A조교B조화C조:FNS、LP수평현저증고(P＜0.05),이ISI수평현저강저(P＜0.05).상관분석발현,A조혈청LP수평여ISI정현저부상관,여FNS정현저정상관.결론 A조LP수평증고,차여IR병존,이자가능공동삼여HCH적발생.
Objective To investigate the changes of leptin level in patients with intracerebral hemorrhage and the relationship between leptin level and insulin resistance(IR). Methods 57 patients with hypertensive cerebral hemorrhage (group A ), 50 patients with hypertension (group B), 41 healthy people (group C) were selected to determine the value of fasting blood-glucose ( FBG), fasting blood-insulin( FBI), leptin levels as well as insulin sensitivity index (ISI). Results The level of FNS and leptin was significantly higher (P ＜ 0.05 ) while the level of ISI was lower (P ＜ 0.05 ) in group A than those in group B and C. Correlation analysis showed that leptin level in HCH patients was negatively correlated with ISI, and positively correlated with FNS. Conclusion The results indicate that higher level of leptin and IR may play an important role in the occurrence of hypertension complicated cerebral hemorrhage.