CAJ | 학술논문

目的通过分析2000个人类结肠癌相关基因以及GO( gene ontology)数据库中与人类生物学过程相关的25 189个基因,揭示蛋白互作比率与基因共调控强度之间的关联趋势.方法基于四联密码子算法提取既包含蛋白互作关系又包含共调控关系的混合模式.应用超几何分布(P≤0.05)筛选出频数大于等于5且具有统计学意义的混合模式1073个.结果蛋白互作比率与基因共调控强度之间存在明显的正相关趋势,即随着蛋白质互作比例的增加,相关基因共调控的强度也随之增强.结论互作蛋白(基因)倾向于被共调控.
목적 통과분석2000개인류결장암상관기인이급GO( gene ontology)수거고중여인류생물학과정상관적25 189개기인,게시단백호작비솔여기인공조공강도지간적관련추세.방법 기우사련밀마자산법제취기포함단백호작관계우포함공조공관계적혼합모식.응용초궤하분포(P≤0.05)사선출빈수대우등우5차구유통계학의의적혼합모식1073개.결과 단백호작비솔여기인공조공강도지간존재명현적정상관추세,즉수착단백질호작비례적증가,상관기인공조공적강도야수지증강.결론 호작단백(기인)경향우피공조공.
Objective By analyzing 2000 human colon carcinoma related genes and 25189 human biology process related genes from GO database,reveal the association tendency of proteins interaction rate and gene co-regulation intension. Methods Base on 4-dimension codon algorithm,we extracted the mixed models,including genes co-regulation relations and proteins interaction relations. Analyze the enrichment property by hypergeometric distribution,and select the 1073 mixed models that appear frequency greater than or equal to 5 and statistics significance ( P ≤0.05 ). Results There is obvious positive correlation between interacting proteins and co-regulation genes. That is,with the increase of protein interaction rate, the strengthen of co-regulated genes is enhanced. Conclusion Interacting proteins related genes are tend to be co-regulated<英文关键词>=Gene co-regulation strengthen;Protein interaction rate;Interaction tendency