国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2009年
1期
29-32
,共4页
狂犬病病毒%抗体%单克隆抗体CR57%单克隆抗体CR40987
狂犬病病毒%抗體%單剋隆抗體CR57%單剋隆抗體CR40987
광견병병독%항체%단극륭항체CR57%단극륭항체CR40987
Rabies virus%Antibodies%Monoclonal antibody CR57%Monoclonal antibody CR4098
狂犬病病毒(rabies virus,RV)感染后的致死率极高,为了替代用于RV暴露后预防的马抗RV免疫球蛋白和人抗RV免疫球蛋白,人们正在进行相关单克隆抗体(单抗)的研究.此文主要阐述了治疗性单抗CR57及其互补单抗CR40987,并讨论了抗RV单抗的表达系统.
狂犬病病毒(rabies virus,RV)感染後的緻死率極高,為瞭替代用于RV暴露後預防的馬抗RV免疫毬蛋白和人抗RV免疫毬蛋白,人們正在進行相關單剋隆抗體(單抗)的研究.此文主要闡述瞭治療性單抗CR57及其互補單抗CR40987,併討論瞭抗RV單抗的錶達繫統.
광견병병독(rabies virus,RV)감염후적치사솔겁고,위료체대용우RV폭로후예방적마항RV면역구단백화인항RV면역구단백,인문정재진행상관단극륭항체(단항)적연구.차문주요천술료치료성단항CR57급기호보단항CR40987,병토론료항RV단항적표체계통.
Rabies is fatal once clinical signs of severe rabies virus (RV) exposure are present.In order to replace rabies immune globulin from human and equine for postexposure prophylaxis of rabis,RV-neutralizing human monoclonal antibodies (mAb) have been investigated extensively.This review summarizes the therapoutic human mAb CR57 and its complementing mAb CR4098.Expresion systems of mAb are also discussed.
